Faltys, Martin; Neto, Ary Serpa; Cioccari, Luca (2024). Physiological changes after fluid bolus therapy in cardiac surgery patients: A propensity score matched case-control study. Critical care and resuscitation, 26(1), pp. 32-40. College of Intensive Care Medicine of Australia and New Zealand 10.1016/j.ccrj.2023.11.005
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OBJECTIVE
Fluid bolus therapy (FBT) is ubiquitous in intensive care units (ICUs) after cardiac surgery. However, its physiological effects remain unclear.
DESIGN
: We performed an electronic health record-based quasi-experimental ICU study after cardiac surgery. We applied propensity score matching and compared the physiological changes after FBT episodes to matched control episodes where despite equivalent physiology no fluid bolus was given.
SETTING
The study was conducted in a multidisciplinary ICU of a tertiary-level academic hospital.
PARTICIPANTS
The study included 2,736 patients who underwent Coronary Artery Bypass Grafting and/or heart valve surgery.
MAIN OUTCOME MEASURES
Changes in cardiac output (CO) and mean arterial pressure (MAP) during the 60 minutes following FBT.
RESULTS
We analysed 3572 matched fluid bolus (FB) episodes. After FBT, but not in control episodes, CO increased within 10 min, with a maximum increase of 0.2 l/min (95%CI 0.1 to 0.2) or 4% above baseline at 40 min (p < 0.0001 vs. controls). CO increased by > 10% from baseline in 60.6% of FBT and 49.1% of control episodes (p < 0.0001). MAP increased by > 10% in 51.7% of FB episodes compared to 53.4% of controls. Finally, FBT was not associated with changes in acid-base status or oxygen delivery.
CONCLUSION
In this quasi-experimental comparative ICU study in cardiac surgery patients, FBT was associated with statistically significant but numerically small increases in CO. Nearly half of FBT failed to induce a positive CO or MAP response.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care |
UniBE Contributor: |
Faltys, Martin, Cioccari, Luca (A) |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1441-2772 |
Publisher: |
College of Intensive Care Medicine of Australia and New Zealand |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
01 May 2024 15:39 |
Last Modified: |
02 May 2024 17:35 |
Publisher DOI: |
10.1016/j.ccrj.2023.11.005 |
PubMed ID: |
38690188 |
Uncontrolled Keywords: |
Cardiac surgery Hypotension Intensive care Resuscitation |
BORIS DOI: |
10.48350/196431 |
URI: |
https://boris.unibe.ch/id/eprint/196431 |
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