Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization.

García-Poyatos, Carolina; Arora, Prateek; Calvo, Enrique; Marques, Ines J; Kirschke, Nick; Galardi-Castilla, Maria; Lembke, Carla; Meer, Marco; Fernández-Montes, Paula; Ernst, Alexander; Haberthür, David; Hlushchuk, Ruslan; Vázquez, Jesús; Vermathen, Peter; Enríquez, José Antonio; Mercader, Nadia (2024). Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization. Developmental cell, 59(14), 1824-1841.e10. Elsevier 10.1016/j.devcel.2024.04.012

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The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV2 formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, cox7a1-/- hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of cox7a1-/- and cox7a2l-/- underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Arora, Prateek, dos Santos Marques, Ines Joao, Kirschke, Nick, Lembke, Carla-Sophie, Meer, Marco Daniel, Ernst, Alexander Uwe Johann, Haberthür, David, Hlushchuk, Ruslan, Vermathen, Peter, Mercader Huber, Nadia Isabel

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1878-1551

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

06 May 2024 11:53

Last Modified:

25 Jul 2024 00:13

Publisher DOI:

10.1016/j.devcel.2024.04.012

PubMed ID:

38701784

Uncontrolled Keywords:

Ca(2+) signaling cox7a1 cox7a2l electron transport chain heart regeneration metabolic rewiring mitochondria muscle physiology scaf1 supercomplex assembly zebrafish

BORIS DOI:

10.48350/196524

URI:

https://boris.unibe.ch/id/eprint/196524

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