Sadat Ahanchi, Noushin; Fischer, Amira Salomé; Quezada-Pinedo, Hugo G; Khatami, Farnaz; Eisenga, Michele F; Muka, Taulant; Vidal, Pedro-Marques (2024). Cross-sectional and longitudinal associations of Iron biomarkers and cardiovascular risk factors in pre- and postmenopausal women: leveraging repeated measurements to address natural variability. Cardiovascular diabetology, 23, p. 158. BioMed Central 10.1186/s12933-024-02242-x
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BACKGROUND
The association between iron biomarkers and cardiovascular disease risk factors (CVD-RFs) remains unclear. We aimed to (1) evaluate the cross-sectional and longitudinal associations between iron biomarkers (serum ferritin, transferrin saturation (TSAT), transferrin) and CVD-RFs among women, and (2) explore if these associations were modified by menopausal status.
METHOD
Cross-sectional and longitudinal analyses including 2542 and 1482 women from CoLaus cohort, respectively. Multiple linear regression and multilevel mixed models were used to analyse the associations between Iron biomarkers and CVD-RFs. Variability of outcomes and iron markers between surveys was accessed using intraclass correlation (ICC).
RESULTS
After multivariable adjustment, elevated serum ferritin levels were associated with increased insulin and glucose levels, while higher transferrin levels were linked to elevated glucose, insulin and total cholesterol, and systolic and diastolic blood pressure (p < 0.05). No association was observed between CVD-RFs and TSAT (p > 0.05). Iron biomarkers demonstrated low reliability across reproductive stages but exhibited stronger associations in the perimenopausal group. In longitudinal analysis, we found association only for transferrin with lower glucose levels [β = - 0.59, 95% CI (- 1.10, - 0.08), p = 0.02] and lower diastolic blood pressure [β = - 7.81, 95% CI (- 15.9, - 0.56), p = 0.04].
CONCLUSION
In cross-sectional analysis, transferrin was associated with several CVD-RFs, and the associations did not change according to menopausal status. Conversely, in the longitudinal analyses, changes in transferrin were associated only with lower glucose and diastolic blood pressure levels. These differences might stem from the substantial longitudinal variation of iron biomarkers, underscoring the need for multiple iron measurements in longitudinal analyses.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Sadat Ahanchi, Noushin, Khatami, Farnaz, Muka, Taulant |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1475-2840 |
Publisher: |
BioMed Central |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 May 2024 10:31 |
Last Modified: |
07 Jun 2024 12:31 |
Publisher DOI: |
10.1186/s12933-024-02242-x |
PubMed ID: |
38715055 |
Additional Information: |
Open Access Funding provided by University of Lausanne. |
Uncontrolled Keywords: |
Cardio-metabolic risk factors Cohort Iron biomarkers Menopause |
BORIS DOI: |
10.48350/196609 |
URI: |
https://boris.unibe.ch/id/eprint/196609 |
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