Aronson, S Lot; Walker, Cédric; Thijssen, Bram; van de Vijver, Koen K; Horlings, Hugo M; Sanders, Joyce; Alkemade, Maartje; Koole, Simone N; Lopez-Yurda, Marta; Lok, Christianne A R; Rottenberg, Sven; van Rheenen, Jacco; Sonke, Gabe S; van Driel, Willemien J; Kester, Lennart A; Hahn, Kerstin (2024). Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1). British journal of cancer, 131(3), pp. 565-576. Springer Nature 10.1038/s41416-024-02731-6
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BACKGROUND
Hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in patients with Stage III ovarian cancer following interval cytoreductive surgery (CRS). Optimising patient selection is essential to maximise treatment efficacy and avoid overtreatment. This study aimed to identify biomarkers that predict HIPEC benefit by analysing gene signatures and cellular composition of tumours from participants in the OVHIPEC-1 trial.
METHODS
Whole-transcriptome RNA sequencing data were retrieved from high-grade serous ovarian cancer (HGSOC) samples from 147 patients obtained during interval CRS. We performed differential gene expression analysis and applied deconvolution methods to estimate cell-type proportions in bulk mRNA data, validated by histological assessment. We tested the interaction between treatment and potential predictors on progression-free survival using Cox proportional hazards models.
RESULTS
While differential gene expression analysis did not yield any predictive biomarkers, the cellular composition, as characterised by deconvolution, indicated that the absence of macrophages and the presence of B cells in the tumour microenvironment are potential predictors of HIPEC benefit. The histological assessment confirmed the predictive value of macrophage absence.
CONCLUSION
Immune cell composition, in particular macrophages absence, may predict response to HIPEC in HGSOC and these hypothesis-generating findings warrant further investigation.
CLINICAL TRIAL REGISTRATION
NCT00426257.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Walker, Cédric André, Rottenberg, Sven |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1532-1827 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Jun 2024 10:42 |
Last Modified: |
07 Aug 2024 00:14 |
Publisher DOI: |
10.1038/s41416-024-02731-6 |
PubMed ID: |
38866963 |
BORIS DOI: |
10.48350/197805 |
URI: |
https://boris.unibe.ch/id/eprint/197805 |
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