Pavicic, Elena; Rüst, Katrin; Ehrentraut, Stefan; von Wolff, Michael; Stute, Petra (2024). The influence of Black Cohosh on hippocampal and hypothalamic gene expression profiles in ovariectomized rats and its potential to treat menopausal decrease in smell discrimination. (In Press). Archives of gynecology and obstetrics Springer 10.1007/s00404-024-07632-w
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PURPOSE
Menopause is associated with a decrease in smell discrimination ability. This study assessed the impact of black cohosh on hippocampal (HC) and hypothalamic (HT) gene expression profiles in rats, to understand, if herbal treatment has an impact on neurologic changes due to menopause and whether this could address a decrease in smell discrimination.
METHODS
HC and HT tissues from female Sprague Dawley rats (total n = 19) were analyzed at three different life stages: intact tissues of the HC (n = 4) and the HT (n = 4), oophorectomized tissues 3 months after oophorectomy (OVX) of the HC (n = 4) and the HT (n = 3), and tissues after treatment with an isopropanolic extract (iCR) from the rhizomes of black cohosh (60 mg/kg) for 3 months after OVX of the HC (n = 2) and the HT (n = 2).
MAIN OUTCOME MEASURES
To reveal underlying biological processes a gene set enrichment analysis (GSEA) was performed.
RESULTS
The GSEA revealed gene ontology terms that were significantly enriched, including several genes associated with the olfactory system, indicating biological processes regulated by treatment with iCR. Six olfactory receptor genes were further analyzed by another GSEA, demonstrating the possibility of iCR treatment to compensate for oophorectomy-induced changes.
CONCLUSION
Findings suggest that herbal treatment, such as iCR, has an esteeming impact on HC and HT genes that are changed through menopause. Further studies are needed to suggest black cohosh as a treatment option for decreased smell discrimination.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
von Wolff, Michael, Stute, Petra |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-0711 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
25 Jul 2024 07:50 |
Last Modified: |
25 Jul 2024 07:59 |
Publisher DOI: |
10.1007/s00404-024-07632-w |
PubMed ID: |
39046467 |
Uncontrolled Keywords: |
Cimicifuga racemose Hippocampus Hypothalamus Menopause Olfactory system |
BORIS DOI: |
10.48350/199184 |
URI: |
https://boris.unibe.ch/id/eprint/199184 |
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