Cartilage tissue engineering for degenerative joint disease

Nesic, Dobrila; Whiteside, Robert; Brittberg, Mats; Wendt, David; Martin, Ivan; Mainil-Varlet, Pierre (2006). Cartilage tissue engineering for degenerative joint disease. Advanced drug delivery reviews, 58(2), pp. 300-22. Amsterdam: Elsevier 10.1016/j.addr.2006.01.012

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Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages. Although many, mostly surgical techniques, are currently employed to treat cartilage lesions, none has given satisfactory results in the long term. Recent advances in biology and material science have brought tissue engineering to the forefront of new cartilage repair techniques. The combination of autologous cells, specifically designed scaffolds, bioreactors, mechanical stimulations and growth factors together with the knowledge that underlies the principles of cell biology offers promising avenues for cartilage tissue regeneration. The present review explores basic biology mechanisms for cartilage reconstruction and summarizes the advances in the tissue engineering approaches. Furthermore, the limits of the new methods and their potential application in the osteoarthritic conditions are discussed.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Service Sector > Institute of Pathology
UniBE Contributor:	Nesic, Dobrila, Mainil, Pierre
ISSN:	0169-409X
ISBN:	16574268
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:48
Last Modified:	05 Dec 2022 14:14
Publisher DOI:	10.1016/j.addr.2006.01.012
PubMed ID:	16574268
Web of Science ID:	000237817100011
URI:	https://boris.unibe.ch/id/eprint/19923 (FactScience: 3001)