Velocity and pattern of growth of intracranial meningiomas.

Häni, Levin; Thomann, Pascal Kilian; Maragkou, Theoni; Vulcu, Sonja; Schütz, Alessa; Jesse, Christopher Marvin; Söll, Nicole; Hakim, Arsany; Raabe, Andreas; Schucht, Philippe (2024). Velocity and pattern of growth of intracranial meningiomas. (In Press). Journal of neurosurgery, pp. 1-8. American Association of Neurological Surgeons 10.3171/2024.4.JNS2446

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OBJECTIVE

The authors' aim was to assess the velocity and pattern of growth of meningiomas and to correlate the kinetics of tumor growth with their previously reported two-item radiological risk stratification and CNS WHO grade (5th edition, 2021).

METHODS

The authors performed a serial volumetric analysis of meningiomas diagnosed radiologically at their institution between 2003 and 2015. The primary endpoint was velocity of diametric expansion (VDE), which represents the slope of the linear regression of the mean tumor diameter against time. For the secondary analysis, they categorized the growth patterns as linear or exponential by fitting time-volume curves to a linear and exponential function. Three radiological risk categories based on T2-weighted iso/hyperintensity and absence of calcifications were compared: low risk (T2-weighted hypointense), intermediate-risk (T2-weighted iso/hyperintense with calcifications), and high-risk (T2-weighted iso/hyperintense without calcifications) tumors.

RESULTS

For the entire cohort of 240 meningiomas, the median (IQR) VDE was 0.33 (0.00-0.71) mm/year. Distribution of VDE differed significantly among radiological risk categories (0.49 vs 0.35 vs 0.05 mm/year, p < 0.001). High-risk and intermediate-risk tumors more frequently tended to grow exponentially compared to low-risk tumors (43.8% vs 37.0% vs 8.3%, p = 0.067). The authors found no correlation of growth velocity with CNS WHO grade in their cohort (1.30 mm/year for CNS WHO grade 1 vs 4.01 mm/year for CNS WHO grade 2, p = 0.185).

CONCLUSIONS

A radiological risk assessment using two parameters-T2-weighted signal iso/hyperintensity and absence of calcifications-allows estimation of growth velocity and characteristics of untreated intracranial meningiomas. Only high-risk tumors exhibit the potential for rapid growth. However, rapid tumor growth does not indicate a higher CNS WHO grade per se.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Häni, Levin, Thomann, Pascal Kilian, Maragkou, Theoni, Vulcu, Sonja, Schütz, Alessa Li-Na, Jesse, Christopher Marvin, Soell, Nicole, Hakim, Arsany, Raabe, Andreas, Schucht, Philippe

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0022-3085

Publisher:

American Association of Neurological Surgeons

Language:

English

Submitter:

Pubmed Import

Date Deposited:

12 Aug 2024 13:53

Last Modified:

12 Aug 2024 13:59

Publisher DOI:

10.3171/2024.4.JNS2446

PubMed ID:

39126728

Uncontrolled Keywords:

asymptomatic incidental meningioma natural history progression tumor

BORIS DOI:

10.48350/199634

URI:

https://boris.unibe.ch/id/eprint/199634

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