Evaluation of the CTSL2 gene as a candidate gene for alopecia X in Pomeranians and Keeshonden

Mausberg, Eva-Maria; Drögemüller, Cord; Leeb, Tosso; Dolf, Gaudenz; Rüfenacht, Silvia; Welle, Monika Maria (2007). Evaluation of the CTSL2 gene as a candidate gene for alopecia X in Pomeranians and Keeshonden. Animal biotechnology, 18(4), pp. 291-6. New York, N.Y.: Marcel Dekker 10.1080/10495390701547461

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Alopecia X is a noninflammatory, progressive, bilateral symmetric alopecia in dogs. The disease is mainly found in Nordic breeds. The breed predisposition and a strong familial accumulation suggest a hereditary background. We analyzed the cathepsin L2 gene (CTSL2) as a candidate for alopecia X. The comparative sequencing of 14 affected and 18 control animals revealed ten polymorphisms; however, none of these polymorphisms affected the coding sequence. Haplotype analysis did not reveal an association of one particular CTSL2 haplotype with the disease phenotype; therefore, we conclude that the CTSL2 gene is probably not the causative gene for alopecia X.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)
UniBE Contributor:	Mausberg, Eva-Maria, Drögemüller, Cord, Leeb, Tosso, Dolf, Gaudenz, Rüfenacht, Silvia, Welle, Monika Maria
Subjects:	600 Technology > 630 Agriculture 500 Science > 590 Animals (Zoology)
ISSN:	1049-5398
Publisher:	Marcel Dekker
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:52
Last Modified:	05 Dec 2022 14:16
Publisher DOI:	10.1080/10495390701547461
PubMed ID:	17934903
Web of Science ID:	000250083600007
URI:	https://boris.unibe.ch/id/eprint/22143 (FactScience: 32030)