Lottaz, Daniel; Buri, Caroline; Monteleone, Giovanni; Rösmann, Sandra; Macdonald, Thomas T; Sanderson, Ian R; Sterchi, Erwin E (2007). Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease. Biological chemistry, 388(3), pp. 337-41. Berlin: Walter de Gruyter 10.1515/BC.2007.038
|
Text
bc.2007.038.pdf - Published Version Available under License Publisher holds Copyright. Download (153kB) | Preview |
Epithelial cells in the human small intestine express meprin, an astacin-like metalloprotease, which accumulates normally at the brush border membrane and in the gut lumen. Therefore, meprin is targeted towards luminal components. In coeliac disease patients, peptides from ingested cereals trigger mucosal inflammation in the small intestine, disrupting epithelial cell differentiation and function. Using in situ hybridisation on duodenal tissue sections, we observed a marked shift of meprin mRNA expression from epithelial cells, the predominant expression site in normal mucosa, to lamina propria leukocytes in coeliac disease. Meprin thereby gains access to the substrate repertoire present beneath the epithelium.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Buri, Caroline, Sterchi, Erwin-Ernst |
ISSN: |
1431-6730 |
ISBN: |
17338642 |
Publisher: |
Walter de Gruyter |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:53 |
Last Modified: |
02 May 2023 15:16 |
Publisher DOI: |
10.1515/BC.2007.038 |
PubMed ID: |
17338642 |
Web of Science ID: |
000244847300011 |
BORIS DOI: |
10.7892/boris.22697 |
URI: |
https://boris.unibe.ch/id/eprint/22697 (FactScience: 36063) |
Actions (login required)
 |
Edit item |