Hepatocellular carcinoma, syncytial giant cell: a novel variant in children: a case report

Atra, A; Al-Asiri, R; Wali, S; Al-Husseini, H; Al-Bassas, A; Zimmermann, A (2007). Hepatocellular carcinoma, syncytial giant cell: a novel variant in children: a case report. Annals of diagnostic pathology, 11(1), pp. 61-3. New York, N.Y.: Elsevier 10.1016/j.anndiagpath.2005.12.005

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Hepatocellular carcinoma (HCC) is the second most common primary malignant hepatic tumor in children. It often develops in patients with underlying liver disease. We report the clinicopathologic features of an unusual HCC occurring in an infant who presented with features of Cushing's syndrome due to bilateral adrenal hyperplasia. The tumor is characterized by epithelial syncytial giant cells. Giant cell carcinoma of the liver has been previously reported, but the cells were osteoclast-like (ie, mesenchymal type) and not epithelial type as it is in this patient. We propose to use the term HCC, syncytial giant cell type, to denote this apparently novel lesion.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Service Sector > Institute of Pathology
UniBE Contributor:	Zimmermann, Arthur
ISSN:	1092-9134
ISBN:	17240310
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:54
Last Modified:	05 Dec 2022 14:16
Publisher DOI:	10.1016/j.anndiagpath.2005.12.005
PubMed ID:	17240310
Web of Science ID:	000248870200011
URI:	https://boris.unibe.ch/id/eprint/22838 (FactScience: 37257)