Gene and protein expression of galectin-3 and galectin-9 in experimental pneumococcal meningitis

Bellac, Caroline L; Coimbra, Roney S; Simon, Franziska; Imboden, Johann; Leib, Stephen L. (2007). Gene and protein expression of galectin-3 and galectin-9 in experimental pneumococcal meningitis. Neurobiology of disease, 28(2), pp. 175-183. Amsterdam: Elsevier 10.1016/j.nbd.2007.07.005

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Inflammation of the subarachnoid and ventricular space contributes to the development of brain damage i.e. cortical necrosis and hippocampal apoptosis in pneumococcal meningitis (PM). Galectin-3 and -9 are known pro-inflammatory mediators and regulators of apoptosis. Here, the gene and protein expression profile for both galectins was assessed in the disease progression of PM. The mRNA of Lgals3 and Lgals9 increased continuously in the cortex and in the hippocampus from 22 h to 44 h after infection. At 44 h after infection, mRNA levels of Lgals9 in the hippocampus were 7-fold and those of Lgals3 were 30-fold higher than in uninfected controls (P<0.01). Galectin-9 protein did not change, but galectin-3 significantly increased in cortex and hippocampus with the duration of PM. Galectin-3 was localized to polymorphonuclear neutrophils, microglia, monocytes and macrophages, suggesting an involvement of galectin-3 in the neuroinflammatory processes leading to brain damage in PM.

Item Type:	Journal Article (Original Article)
Division/Institute:	08 Faculty of Science > Department of Biology > Institute of Cell Biology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
UniBE Contributor:	Imboden, Johann, Leib, Stephen
ISSN:	0969-9961
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:56
Last Modified:	05 Dec 2022 14:17
Publisher DOI:	10.1016/j.nbd.2007.07.005
PubMed ID:	17706429
Web of Science ID:	000251124700004
URI:	https://boris.unibe.ch/id/eprint/23927 (FactScience: 45259)