Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo

Fathi, Ali Reza; Marbacher, Serge; Graupner, Thilo; Wehrli, Felix; Jakob, Stephan M; Schroth, Gerhard; Fandino, Javier (2011). Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo. Acta neurochirurgica, 153(8), pp. 1669-1675. Wien: Springer Vienna 10.1007/s00701-011-1049-7

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Delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is a major cause of high morbidity and mortality. The reduced availability of nitric oxide (NO) in blood and cerebrospinal fluid (CSF) is well established as a key mechanism of vasospasm. Systemic administration of glyceryl trinitrate (GTN), an NO donor also known as nitroglycerin, has failed to be established in clinical settings to prevent vasospasm because of its adverse effects, particularly hypotension. The purpose of this study was to analyze the effect of intrathecally administered GTN on vasospasm after experimental SAH in the rabbit basilar artery.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie

UniBE Contributor:

 Fathi, Ali Reza, Marbacher, Serge, Graupner, Thilo, Jakob, Stephan, Schroth, Gerhard, Fandino, Javier

ISSN:

 0001-6268

Publisher:

 Springer Vienna

Language:

 English

Submitter:

 Factscience Import

Date Deposited:

 04 Oct 2013 14:12

Last Modified:

 05 Dec 2022 14:01

Publisher DOI:

 10.1007/s00701-011-1049-7

PubMed ID:

 21671141

Web of Science ID:

 000292925000018

Additional Information:

Discussion on page 1675

BORIS DOI:

 10.7892/boris.2458

URI:

 https://boris.unibe.ch/id/eprint/2458 (FactScience: 204995)

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