Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitis

Kim, YS; Honkaniemi, J; Sharp, FR; Täuber, MG (2004). Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitis. Molecular brain research, 128(1), pp. 95-102. Amsterdam: Elsevier 10.1016/j.molbrainres.2004.06.009

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We performed mRNA in situ hybridization for TNF-alpha and IL-1beta from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1beta mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
UniBE Contributor:	Täuber, Martin G.
ISSN:	0169-328X
ISBN:	15337322
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:00
Last Modified:	05 Dec 2022 14:18
Publisher DOI:	10.1016/j.molbrainres.2004.06.009
PubMed ID:	15337322
Web of Science ID:	000223878900011
URI:	https://boris.unibe.ch/id/eprint/25716 (FactScience: 60798)