Fischer, L; Kleeff, J; Esposito, I; Hinz, U; Zimmermann, A; Friess, H; Büchler, M W (2008). Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas. British journal of surgery, 95(5), pp. 627-35. Bristol, UK: John Wright & Sons 10.1002/bjs.6051
Full text not available from this repository. (Request a copy)BACKGROUND: The aim was to assess the clinical relevance of the World Health Organization and tumour node metastasis (TNM) classifications in patients with pancreatic neuroendocrine tumours (pNETs). METHODS: Prospectively collected data from 118 consecutive patients with a pNET receiving surgical intervention were analysed. RESULTS: Forty-one patients had well differentiated neuroendocrine tumours, 64 had well differentiated neuroendocrine carcinomas and 13 had poorly differentiated neuroendocrine carcinomas. Five-year survival rates were 95, 44 and 0 per cent respectively (P < 0.001). There was no difference in survival after R0 and R1/R2 resections in patients with neuroendocrine carcinomas (P = 0.905). In those with well differentiated neuroendocrine carcinomas, any resection and having a clinically non-functional tumour significantly increased survival (P = 0.003 and P = 0.037 respectively). The TNM stage was I in 37 patients, II in 15 patients, III in 32 patients and IV in 34 patients. There were significant differences in 5-year survival between stage I and II (88 and 85 per cent respectively) and stage III and IV (31 and 42 per cent respectively) (P = 0.010). CONCLUSION: Both classifications accurately reflect the clinical outcome of patients with pNET. The resection status may not be critical for long-term survival in patients with pNET.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Zimmermann, Arthur |
ISSN: |
0007-1323 |
ISBN: |
18306152 |
Publisher: |
John Wright & Sons |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:02 |
Last Modified: |
05 Dec 2022 14:19 |
Publisher DOI: |
10.1002/bjs.6051 |
PubMed ID: |
18306152 |
Web of Science ID: |
000255794100015 |
URI: |
https://boris.unibe.ch/id/eprint/26899 (FactScience: 96355) |
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