The nuclear factor-kappaB and p53 pathways function independently in primary cells and transformed fibroblasts responding to genotoxic damage

Nesic, Dobrila; Grumont, Raelene; Gerondakis, Steve (2008). The nuclear factor-kappaB and p53 pathways function independently in primary cells and transformed fibroblasts responding to genotoxic damage. Molecular cancer research, 6(7), pp. 1193-203. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1541-7786.MCR-07-2125

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With nuclear factor-kappaB (NF-kappaB) and p53 functions generally having disparate outcomes for cell survival and cell division, understanding how these pathways are coordinated following a common activation signal such as DNA damage has important implications for cancer therapy. Conflicting reports concerning NF-kappaB and p53 interplay in different cell line models prompted a reexamination of this issue using mouse primary thymocytes and embryonic fibroblasts, plus fibroblasts transformed by E1A12S. Here, we report that following the treatment of these cells with a range of stress stimuli, p53 and NF-kappaB were found to regulate cell cycling and survival independently.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Service Sector > Institute of Pathology
UniBE Contributor:	Nesic, Dobrila
ISSN:	1541-7786
ISBN:	18583526
Publisher:	American Association for Cancer Research AACR
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:02
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1158/1541-7786.MCR-07-2125
PubMed ID:	18583526
Web of Science ID:	000257895900012
URI:	https://boris.unibe.ch/id/eprint/27147 (FactScience: 104597)