Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro

Helfenstein, Maria; Miragoli, Michele; Rohr, Stephan; Müller, Loretta; Wick, Peter; Mohr, Martin; Gehr, Peter; Rothen-Rutishauser, Barbara (2008). Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro. Toxicology, 253(1-3), pp. 70-8. Amsterdam: Elsevier 10.1016/j.tox.2008.08.018

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Evidence from epidemiological studies indicates that acute exposure to airborne pollutants is associated with an increased risk of morbidity and mortality attributed to cardiovascular diseases. The present study investigated the effects of combustion-derived ultrafine particles (diesel exhaust particles) as well as engineered nanoparticles (titanium dioxide and single-walled carbon nanotubes) on impulse conduction characteristics, myofibrillar structure and the formation of reactive oxygen species in patterned growth strands of neonatal rat ventricular cardiomyocytes in vitro. Diesel exhaust particles as well as titanium dioxide nanoparticles showed the most pronounced effects. We observed a dose-dependent change in heart cell function, an increase in reactive oxygen species and, for titanium dioxide, we also found a less organized myofibrillar structure. The mildest effects were observed for single-walled carbon nanotubes, for which no clear dose-dependent alterations of theta and dV/dt(max) could be determined. In addition, there was no increase in oxidative stress and no change in the myofibrillar structure. These results suggest that diesel exhaust as well as titanium dioxide particles and to a lesser extent also single-walled carbon nanotubes can directly induce cardiac cell damage and can affect the function of the cells.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Pneumologie (Erwachsene)
UniBE Contributor:	Helfenstein, Maria, Miragoli, Michele, Rohr, Stephan, Müller, Loretta Lina (B), Gehr, Peter, Rothen-Rutishauser, Barbara
ISSN:	0300-483X
ISBN:	18824210
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:03
Last Modified:	29 Mar 2023 23:33
Publisher DOI:	10.1016/j.tox.2008.08.018
PubMed ID:	18824210
Web of Science ID:	000261531800048
URI:	https://boris.unibe.ch/id/eprint/27555 (FactScience: 108819)