Combined meropenem and linezolid as a systemic treatment for postoperative endophthalmitis

Tappeiner, Christoph; Schürch, Kaspar Werner; Goldblum, David; Zimmerli, Stefan; Fleischhauer, Johannes M.C.; Früh Epstein, Beatrice (2010). Combined meropenem and linezolid as a systemic treatment for postoperative endophthalmitis. Klinische Monatsblätter für Augenheilkunde, 227(4), pp. 257-61. Stuttgart: Ferdinand Enke Verlag 10.1055/s-0029-1245219

Full text not available from this repository.

PURPOSE The aim of this study was to evaluate the antibiotic treatment of postoperative endophthalmitis with combined systemic meropenem and linezolid. METHODS A retrospective analysis of endophthalmitis treated with systemic meropenem and linezolid compared to conventional systemic antibiotics by evaluation of outcome and adverse effects was carried out. RESULTS 26 patients with unilateral postoperative endophthalmitis with a systemic combination regimen of meropenem (2 g TID, mean duration of treatment 5.5 days) and linezolid (600 mg BID, mean duration of treatment 8.9 days) (group 1, mean follow-up time 140 days) were included in this study and compared to 45 postoperative endophthalmitis patients treated with conventional systemic antibiotics (group 2; mean follow-up time 320 days). In group 1, 69.2 % of eyes additionally received intravitreal amikacin and vancomycin (vs. 24.4 % in group 2; p < 0.001), in 92.3 % pars plana vitrectomy was performed (vs. 68.9 % in group 2, p = 0.047). Mean best corrected visual acuity improved from a baseline of 1.76 logMar for group 1 and 1.83 logMar for group 2 to 0.91 logMar (p = 0.0001) and 0.90 logMar (p < 0.0001), respectively, at the end of the follow-up, revealing no significant differences between the two groups at any time point (p > 0.05). Ocular complications were observed in 34.6 % of eyes in group 1 (vs. 37.8 % in group 2; p > 0.05). Adverse drug effects occurred significantly more frequently in group 1 (26.9 % vs. 4.4 % p = 0.02). CONCLUSION In spite of the reported better penetration through the blood-ocular barrier and the broader antibacterial spectrum of meropenem and linezolid, no benefit in outcome was found in the present study. In contrast, adverse effects and costs of the combination regimen were significantly higher.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
UniBE Contributor:	Tappeiner, Christoph, Schürch, Kaspar Werner, Goldblum, David, Zimmerli, Stephan, Früh Epstein, Beatrice
Subjects:	600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology
ISSN:	0023-2165
Publisher:	Ferdinand Enke Verlag
Language:	English
Submitter:	Christoph Tappeiner
Date Deposited:	04 Oct 2013 14:08
Last Modified:	02 Mar 2023 23:20
Publisher DOI:	10.1055/s-0029-1245219
PubMed ID:	20408069
Web of Science ID:	000276863200006
URI:	https://boris.unibe.ch/id/eprint/303 (FactScience: 197478)