Passarella, Daniele; Comi, Daniela; Cappelletti, Graziella; Cartelli, Daniele; Gertsch, Juerg; Quesada, Ana R; Borlak, Jurgen; Altmann, Karl-Heinz (2009). Synthesis and biological evaluation of epothilone A dimeric compounds. Bioorganic & medicinal chemistry, 17(21), pp. 7435-40. Amsterdam: Elsevier 10.1016/j.bmc.2009.09.032
Full text not available from this repository. (Request a copy)The preparation and biological evaluation of a novel series of dimeric epothilone A derivatives (1-6) are described. Two types of diacyl spacers were introduced to establish the various dimeric epothilone A constructs. The effect of these compounds on tubulin polymerization and their cytotoxicity against four different cancer cell lines are reported. Several of the newly synthesized compounds inhibit endothelial cell differentiation and endothelial cell migration that are key steps of the angiogenic process.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Gertsch, Jürg |
ISSN: |
0968-0896 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:12 |
Last Modified: |
05 Dec 2022 14:22 |
Publisher DOI: |
10.1016/j.bmc.2009.09.032 |
PubMed ID: |
19804980 |
Web of Science ID: |
000270903100004 |
URI: |
https://boris.unibe.ch/id/eprint/31617 (FactScience: 196248) |
Actions (login required)
 |
Edit item |