Living and dying for inflammation: neutrophils, eosinophils, basophils

Geering, Barbara; Stoeckle, Christina; Conus, Sébastien; Simon, Hans-Uwe (2013). Living and dying for inflammation: neutrophils, eosinophils, basophils. Trends in immunology, 34(8), pp. 398-409. Elsevier Current Trends 10.1016/j.it.2013.04.002

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Neutrophils, eosinophils, and basophils play essential roles during microbe-induced and sterile inflammation. The severity of such inflammatory processes is controlled, at least in part, by factors that regulate cell death and survival of granulocytes. In recent years, major progress has been made in understanding the molecular mechanisms of granulocyte cell death and in identifying novel damage- and pathogen-associated molecular patterns as well as regulatory cytokines impacting granulocyte viability. Furthermore, an increased interest in innate immunity has boosted our overall understanding of granulocyte biology. In this review, we describe and compare factors and mechanisms regulating neutrophil, eosinophil, and basophil lifespan. Because dysregulation of death pathways in granulocytes can contribute to inflammation-associated immunopathology, targeting granulocyte lifespan could be therapeutically promising.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
UniBE Contributor:	Geering Truffer, Barbara, Merz, Christina, Conus, Sébastien, Simon, Hans-Uwe
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1471-4906
Publisher:	Elsevier Current Trends
Language:	English
Submitter:	Anita Dähler
Date Deposited:	04 Apr 2014 02:09
Last Modified:	05 Dec 2022 14:28
Publisher DOI:	10.1016/j.it.2013.04.002
PubMed ID:	23665135
Uncontrolled Keywords:	Apoptosis, DAMPs, PAMPs, cytokines, granulocytes, inflammation
URI:	https://boris.unibe.ch/id/eprint/42613