Gendron, Karine; Owczarek-Lipska, Marta; Lang, Johann; Leeb, Tosso (2013). Maine Coon renal screening: ultrasonographical characterisation and preliminary genetic analysis for common genes in cats with renal cysts. Journal of feline medicine and surgery, 15(12), pp. 1079-1085. Sage 10.1177/1098612X13492164
Full text not available from this repository.The objective of this study was to assess the prevalence of renal cysts and other renal abnormalities in purebred Maine Coon cats, and to characterise these through genetic typing. Voluntary pre-breeding screening programmes for polycystic kidney disease (PKD) are offered for this breed throughout Switzerland, Germany and other northern European countries. We performed a retrospective evaluation of Maine Coon screening for renal disease at one institution over an 8-year period. Renal ultrasonography was performed in 187 healthy Maine Coon cats. Renal changes were observed in 27 of these cats. Renal cysts were found in seven cats, and were mostly single and unilateral (6/7, 85.7%), small (mean 3.6 mm) and located at the corticomedullary junction (4/6, 66.7%). Sonographical changes indicating chronic kidney disease (CKD) were observed in 10/187 (5.3%) cats and changes of unknown significance were documented in 11/187 (5.9%) cats. All six cats genetically tested for PKD1 were negative for the mutation, and gene sequencing of these cats did not demonstrate any common genetic sequences. Cystic renal disease occurs with a low prevalence in Maine Coons and is unrelated to the PKD observed in Persians and related breeds. Ultrasonographical findings compatible with CKD are not uncommon in juvenile Maine Coons.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology |
UniBE Contributor: |
Gendron, Karine, Owczarek, Marta, Lang-Fritz, Johann, Leeb, Tosso |
Subjects: |
500 Science > 590 Animals (Zoology) 600 Technology > 630 Agriculture |
ISSN: |
1098-612X |
Publisher: |
Sage |
Language: |
English |
Submitter: |
Susanne Portner |
Date Deposited: |
04 Jul 2014 14:40 |
Last Modified: |
02 Mar 2023 23:24 |
Publisher DOI: |
10.1177/1098612X13492164 |
PubMed ID: |
23735675 |
URI: |
https://boris.unibe.ch/id/eprint/43863 |
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