Simonetti, Sara; Terracciano, Luigi; Zlobec, Inti; Kilic, Ergin; Stasio, Loredana; Quarto, Maria; Pettinato, Guido; Insabato, Luigi (2012). Immunophenotyping analysis in invasive micropapillary carcinoma of the breast: Role of CD24 and CD44 isoforms expression. Breast, 21(2), pp. 165-70. Amsterdam: Elsevier 10.1016/j.breast.2011.09.004
Full text not available from this repository. (Request a copy)We analyzed immunohistochemically the expression of CD24 and spliced variants of CD44v5 and v9 in invasive micropapillary carcinoma (IMPC) of the breast that is a rather aggressive tumor characterized by alteration of cells adhesion molecules, early lymph node metastases and poor prognosis. We analyzed 31 high-grade IMPCs and compared their expression to 22 high grade (G3) invasive ductal carcinomas of the breast (IDCs). We found a higher expression of CD24 in high-grade IMPCs with a peculiar inverted apical localization, compared to IDCs, showing a strong cytoplasmic staining; normal breast tissue resulted completely negative. IMPCs showed reduced expression of CD44v5 and CD44v9 compared with IDCs, but without a statistical significant difference. This study demonstrated that IMPC represents a distinct entity of breast carcinoma with high expression of CD24 with a typical inverted apical membrane pattern and reduction of CD44 isoforms v5 and v9, compared to IDCs. These features could explain the high lymph-vascular invasion propensity and higher metastatic capability of these tumors and could be a useful tool for a future targeted therapy.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Terracciano, Luigi, Zlobec, Inti |
ISSN: |
0960-9776 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:17 |
Last Modified: |
05 Dec 2022 14:04 |
Publisher DOI: |
10.1016/j.breast.2011.09.004 |
PubMed ID: |
22014860 |
Web of Science ID: |
000268307700101 |
URI: |
https://boris.unibe.ch/id/eprint/5012 (FactScience: 209711) |
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