Leib, Stephen; Täuber, Martin G. (1999). Pathogenesis of bacterial meningitis. Infectious disease clinics of North America, 13(3), pp. 527-548. Elsevier 10.1016/S0891-5520(05)70093-3
Full text not available from this repository.Bacterial meningitis is fatal in 5% to 40% of patients and causes neurologic sequelae in up to 30% of survivors. Much has been learned recently about the mechanisms that lead to brain injury during meningitis. Once bacteria have gained access to the central nervous system, their multiplication triggers a complex host response consisting of humoral and cellular immune mediators, reactive oxygen intermediates, matrix-metalloproteinases, and other host-derived factors. Alterations of the cerebral vasculature, with disruption of the blood brain barrier and global and focal ischemia, ultimately lead to functional and structural brain damage. This article reviews current concepts of the pathophysiology of bacterial meningitis and emphasizes possible therapeutic strategies to prevent its harmful consequences.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine |
UniBE Contributor: |
Leib, Stephen, Täuber, Martin G. |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0891-5520 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Stephen Leib |
Date Deposited: |
01 Sep 2014 14:37 |
Last Modified: |
05 Dec 2022 14:34 |
Publisher DOI: |
10.1016/S0891-5520(05)70093-3 |
PubMed ID: |
10470554 |
Web of Science ID: |
000082172400003 |
URI: |
https://boris.unibe.ch/id/eprint/52774 (FactScience: 60887) |
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