Mosimann, Markus; Küpfer, Pascal A.; Leumann, Christian J. (2005). Synthesis and incorporation into DNA of a chemically stable, functional abasic site analogue. Organic letters, 7(23), pp. 5211-5214. American Chemical Society 10.1021/ol052045g
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[reaction: see text] The abasic site building block 7 for DNA synthesis, containing a methylenephosphinic acid group at C3', was prepared in six steps and was incorporated into DNA via a combination of H-phosphonate and phosphoramidite chemistry. Corresponding oligodeoxynucleotides were shown to be chemically stable under basic conditions and fully functional at the respective hemiacetal center
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Mosimann, Markus (A), Küpfer, Pascal, Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1523-7060 |
Publisher: |
American Chemical Society |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
26 May 2014 15:03 |
Last Modified: |
29 Mar 2023 23:34 |
Publisher DOI: |
10.1021/ol052045g |
PubMed ID: |
16268540 |
Uncontrolled Keywords: |
abasic, ACID, analogue, Biochemistry, chemistry, DNA, H-phosphonate, Oligodeoxynucleotides, phosphoramidite site, synthesis |
BORIS DOI: |
10.7892/boris.53109 |
URI: |
https://boris.unibe.ch/id/eprint/53109 |
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