Weber, Benjamin; Saurer, Leslie; Schenk, Mirjam; Dickgreber, Nina; Mueller, Christoph (2011). CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions. European journal of immunology, 41(3), pp. 773-779. Weinheim: Wiley-VCH 10.1002/eji.201040965
Full text not available from this repository. (Request a copy)Intestinal mononuclear phagocytes (iMNP) are critically involved in mucosal immunity and tissue homeostasis. Two major non-overlapping populations of iMNP have been identified in mice. CD103(+) iMNP represent a migratory population capable of inducing tolerogenic responses, whereas CX3CR1(+) iMNP are resident cells with disease-promoting potential. CX3CR1(+) iMNP can further be subdivided based on differential expression of CX3CR1. Using CX3CR1(GFP/+) ×RAG2(-/-) mice, we demonstrate that CX3CR1(hi) and CX3CR1(lo) iMNP clearly differ with respect to their morphological and functional properties. Compared with CX3CR1(hi) iMNP, CX3CR1(lo) iMNP are polarised towards pro-inflammatory responses already under homeostatic conditions. During a CD4(+) T-cell-induced colitis, CX3CR1(lo) cells accumulate in the inflamed mucosa and upregulate the expression of pro-inflammatory cytokines and triggering receptor expressed on myeloid cells-1 (TREM-1). In contrast, CX3CR1(hi) iMNP retain their non-inflammatory profile even during intestinal inflammation. These findings identify two functionally distinct iMNP subsets based on differential expression of CX3CR1 and indicate an unanticipated stability of iMNP.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Weber, Benjamin, Saurer, Leslie, Schenk, Mirjam, Dickgreber, Nina, Müller, Christoph (C) |
ISSN: |
0014-2980 |
Publisher: |
Wiley-VCH |
Language: |
English |
Submitter: |
Christa Hagert |
Date Deposited: |
04 Oct 2013 14:18 |
Last Modified: |
29 Mar 2023 23:32 |
Publisher DOI: |
10.1002/eji.201040965 |
PubMed ID: |
21341263 |
Web of Science ID: |
000288097700022 |
URI: |
https://boris.unibe.ch/id/eprint/5526 (FactScience: 210279) |
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