Marbacher, Serge; Nevzati, Edin; Croci, Davide; Erhardt, Salome; Muroi, Carl; Jakob, Stephan; Fandino, Javier (2014). The Rabbit Shunt Model of Subarachnoid Haemorrhage. Translational stroke research, 5(6), pp. 669-680. Springer 10.1007/s12975-014-0369-3
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Aneurysmal subarachnoid haemorrhage (SAH) is a disease with devastating complications that leads to stroke, permanent neurological deficits and death. Clinical and ex-perimental work has demonstrated the importance of the contribution of delayed cerebral vasospasm (DCVS) indepen-dent early events to mortality, morbidity and functional out-come after SAH. In order to elucidate processes involved in early brain injury (EBI), animal models that reflect acute events of aneurysmal bleeding, such as increase in intracranial pressure (ICP) and decrease in cerebral perfusion pressure, are needed. In the presented arterial shunt model, bleeding is initially driven by the pressure gradient between mean arterial blood pressure and ICP. SAH dynamics (flow rate, volume and duration) depend on physiological reactions and local anatomical intrathecal (cistern) conditions. During SAH, ICP reaches a plateau close to diastolic arterial blood pressure and the blood flow stops. Historical background, anaesthesia, perioperative care and monitoring, SAH induction, technical considerations and advantages and limitations of the rabbit blood shunt SAH model are discussed in detail. Awareness of technical details, physiological characteristics and appropriate monitoring methods guarantees successful implementation of the rabbit blood shunt model and allows the study of both EBI and DCVS after SAH.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie |
UniBE Contributor: |
Jakob, Stephan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1868-4483 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Alessandra Angelini |
Date Deposited: |
16 Feb 2015 11:16 |
Last Modified: |
05 Dec 2022 14:39 |
Publisher DOI: |
10.1007/s12975-014-0369-3 |
PubMed ID: |
25326333 |
BORIS DOI: |
10.48350/62795 |
URI: |
https://boris.unibe.ch/id/eprint/62795 |
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