Egger, Julian; Bretscher, Peter; Freigang, Stefan Bernd; Kopf, Manfred; Carreira, Erick M (2014). Discovery of a highly potent anti-inflammatory epoxyisoprostane-derived lactone. Journal of the American Chemical Society, 136(50), pp. 17382-17385. American Chemical Society 10.1021/ja509892u
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Epoxyisoprostanes EI (1) and EC (2) are effective inhibitors of the secretion of proinflammatory cytokines IL-6 and IL-12. In detailed studies toward the investigation of the molecular mode of action of these structures, a highly potent lactone (3) derived from 1 was identified. The known isoprostanoids 1 and 2 are most likely precursors of 3, the product of facile intramolecular reaction between the epoxide with the carboxylic acid in 2.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology 04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology |
UniBE Contributor: |
Freigang, Stefan Bernd |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0002-7863 |
Publisher: |
American Chemical Society |
Language: |
English |
Submitter: |
Doris Haefelin |
Date Deposited: |
23 Feb 2015 08:18 |
Last Modified: |
05 Dec 2022 14:41 |
Publisher DOI: |
10.1021/ja509892u |
PubMed ID: |
25474746 |
BORIS DOI: |
10.7892/boris.63561 |
URI: |
https://boris.unibe.ch/id/eprint/63561 |
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