Danilowicz, Emilia; Akouchekian, Mansoureh; Drögemüller, Cord; Haase, Bianca; Leeb, Tosso; Kuiper, Heidi; Distl, Ottmar; Iras, Fugato-Consortium (2008). Molecular characterization and SNP development for the porcine IL6 and IL10 genes. Animal biotechnology, 19(3), pp. 159-165. Marcel Dekker 10.1080/10495390802088621
Full text not available from this repository. (Request a copy)Different cytokines are secreted in response to specific microbial molecules referred to as pathogen associated molecular patterns (PAMPs). Interleukin 6 (IL6) and interleukin 10 (IL10), both secreted by macrophages and lymphocytes, play a central role in the immunological response. In this work we obtained the genomic structure and complete DNA sequence of the porcine IL6 and IL10 genes and identified polymorphisms in the genomic sequences of these genes on a panel of ten different pig breeds. Comparative intra- and interbreed sequence analysis revealed a total of eight polymorphisms in the porcine IL6 gene and 21 in the porcine IL10 gene, which include single nucleotide polymorphisms (SNPs) and insertion deletion polymorphisms (indels). Additionally, the chromosomal localization of the IL10 gene was determined by FISH and RH mapping.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) |
UniBE Contributor: |
Danilowicz, Emilia, Akouchekian, Mansoureh, Drögemüller, Cord, Haase, Bianca, Leeb, Tosso |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 590 Animals (Zoology) 600 Technology > 610 Medicine & health 600 Technology > 630 Agriculture |
ISSN: |
1049-5398 |
Publisher: |
Marcel Dekker |
Language: |
English |
Submitter: |
Tosso Leeb |
Date Deposited: |
17 Aug 2015 14:09 |
Last Modified: |
05 Dec 2022 14:48 |
Publisher DOI: |
10.1080/10495390802088621 |
PubMed ID: |
18607788 |
URI: |
https://boris.unibe.ch/id/eprint/70780 |
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