Diafa, Stella; Hollenstein, Marcel (2015). Generation of Aptamers with an Expanded Chemical Repertoire. Molecules, 20(9), pp. 16643-16671. Molecular Diversity Preservation International MDPI 10.3390/molecules200916643
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The enzymatic co-polymerization of modified nucleoside triphosphates (dN*TPs and N*TPs) is a versatile method for the expansion and exploration of expanded chemical space in SELEX and related combinatorial methods of in vitro selection. This strategy can be exploited to generate aptamers with improved or hitherto unknown properties. In this review, we discuss the nature of the functionalities appended to nucleoside triphosphates and their impact on selection experiments. The properties of the resulting modified aptamers will be described, particularly those integrated in the fields of biomolecular diagnostics, therapeutics, and in the expansion of genetic systems (XNAs).
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Diafa, Stella, Hollenstein, Marcel |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1420-3049 |
Publisher: |
Molecular Diversity Preservation International MDPI |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Marcel Hollenstein |
Date Deposited: |
03 Nov 2015 14:22 |
Last Modified: |
05 Dec 2022 14:49 |
Publisher DOI: |
10.3390/molecules200916643 |
PubMed ID: |
26389865 |
BORIS DOI: |
10.7892/boris.72412 |
URI: |
https://boris.unibe.ch/id/eprint/72412 |
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