Cioccari, Luca; Gautschi, Matthias; Etter, Reto; Weck, Anja; Takala, Jukka (2015). Further Concerns About Glutamine: A Case Report on Hyperammonemic Encephalopathy. Critical care medicine, 43(10), e458-e460. Lippincott Williams & Wilkins 10.1097/CCM.0000000000001151
|
Text
00003246-201510000-00046.pdf - Published Version Available under License Publisher holds Copyright. Download (632kB) | Preview |
OBJECTIVE
We report a case of a woman with hyperammonemic encephalopathy following glutamine supplementation.
DESIGN
Case report.
INTERVENTIONS
Plasma amino acid analysis suggestive of a urea cycle defect and initiation of a treatment with lactulose and the two ammonia scavenger drugs sodium benzoate and phenylacetate. Together with a restricted protein intake ammonia and glutamine plasma levels decreased with subsequent improvement of the neurological status.
MEASUREMENTS AND MAIN RESULTS
Massive catabolism and exogenous glutamine administration may have contributed to hyperammonemia and hyperglutaminemia in this patient.
CONCLUSION
This case adds further concerns regarding glutamine administration to critically ill patients and implies the importance of monitoring ammonia and glutamine serum levels in such patients.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care |
UniBE Contributor: |
Gautschi, Matthias, Etter, Reto, Weck, Anja, Takala, Jukka |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0090-3493 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Alessandra Angelini |
Date Deposited: |
04 Feb 2016 09:54 |
Last Modified: |
05 Dec 2022 14:51 |
Publisher DOI: |
10.1097/CCM.0000000000001151 |
PubMed ID: |
26035146 |
BORIS DOI: |
10.7892/boris.74867 |
URI: |
https://boris.unibe.ch/id/eprint/74867 |
Actions (login required)
 |
Edit item |