Computed Ultrasound Tomography in Echo Mode for Imaging Speed of Sound Using Pulse-Echo Sonography: Proof of Principle

Jaeger, Michael; Held, Kai Gerrit; Peeters, Sara Elisa; Preisser, Stefan; Grünig, Michael; Frenz, Martin (2015). Computed Ultrasound Tomography in Echo Mode for Imaging Speed of Sound Using Pulse-Echo Sonography: Proof of Principle. Ultrasound in medicine & biology, 41(1), pp. 235-250. Elsevier 10.1016/j.ultrasmedbio.2014.05.019

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The limitations of diagnostic echo ultrasound have motivated research into novel modalities that complement ultrasound in a multimodal device. One promising candidate is speed of sound imaging, which has been found to reveal structural changes in diseased tissue. Transmission ultrasound tomography shows speed of sound spatially resolved, but is limited to the acoustically transparent breast. We present a novel method by which speed-of-sound imaging is possible using classic pulse-echo equipment, facilitating new clinical applications and the combination with state-of-the art diagnostic ultrasound. Pulse-echo images are reconstructed while scanning the tissue under various angles using transmit beam steering. Differences in average sound speed along different transmit directions are reflected in the local echo phase, which allows a 2-D reconstruction of the sound speed. In the present proof-of-principle study, we describe a contrast resolution of 0.6% of average sound speed and a spatial resolution of 1 mm (laterally) × 3 mm (axially), suitable for diagnostic applications.

Item Type:	Journal Article (Original Article)
Division/Institute:	08 Faculty of Science > Institute of Applied Physics 08 Faculty of Science > Institute of Applied Physics > Biomedical Photonics
UniBE Contributor:	Jaeger, Michael, Held, Kai Gerrit, Peeters, Sara Elisa, Preisser, Stefan, Grünig, Michael, Frenz, Martin
Subjects:	600 Technology > 620 Engineering 500 Science 500 Science > 530 Physics
ISSN:	0301-5629
Publisher:	Elsevier
Language:	English
Submitter:	Martin Frenz-Lips
Date Deposited:	04 Feb 2016 10:54
Last Modified:	05 Dec 2022 14:51
Publisher DOI:	10.1016/j.ultrasmedbio.2014.05.019
URI:	https://boris.unibe.ch/id/eprint/74982