Braun, Benedikt J.; Slowik, Alexander; Leib, Stephen L.; Lucius, Ralph; Varoga, Deike; Wruck, Christoph J.; Jansen, Sandra; Podschun, Rainer; Pufe, Thomas; Brandenburg, Lars-Ove (2011). The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis. Journal of neuroinflammation, 8(1), p. 11. London: BioMed Central 10.1186/1742-2094-8-11
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Recent studies have suggested that the scavenger receptor MARCO (macrophage receptor with collagenous structure) mediates activation of the immune response in bacterial infection of the central nervous system (CNS). The chemotactic G-protein-coupled receptor (GPCR) formyl-peptide-receptor like-1 (FPRL1) plays an essential role in the inflammatory responses of host defence mechanisms and neurodegenerative disorders such as Alzheimer's disease (AD). Expression of the antimicrobial peptide cathelicidin CRAMP/LL-37 is up-regulated in bacterial meningitis, but the mechanisms underlying CRAMP expression are far from clear.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Leib, Stephen |
ISSN: |
1742-2094 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:24 |
Last Modified: |
05 Dec 2022 14:07 |
Publisher DOI: |
10.1186/1742-2094-8-11 |
PubMed ID: |
21299846 |
Web of Science ID: |
000287452900001 |
BORIS DOI: |
10.7892/boris.8289 |
URI: |
https://boris.unibe.ch/id/eprint/8289 (FactScience: 213806) |
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