De Niz Hidalgo, Mariana Isabel; Ullrich, Ann-Katrin; Heiber, Arlett; Blancke Soares, Alexandra; Pick, Christian; Lyck, Ruth; Keller, Derya; Kaiser, Gesine; Prado, Monica; Flemming, Sven; Del Portillo, Hernando; Janse, Chris J; Heussler, Volker; Spielmann, Tobias (2016). The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites. Nature communications, 7, p. 11659. Nature Publishing Group 10.1038/ncomms11659
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Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent parasite. Here we identify the P. berghei orthologues of two such key factors of P. falciparum, SBP1 and MAHRP1. Red blood cells infected with P. berghei parasites lacking SBP1 or MAHRP1a fail to bind the endothelial receptor CD36 and show reduced sequestration and virulence in mice. Complementation of the mutant P. berghei parasites with the respective P. falciparum SBP1 and MAHRP1 orthologues restores sequestration and virulence. These findings reveal evolutionary conservation of the machinery underlying sequestration of divergent malaria parasites and support the notion that the P. berghei rodent model is an adequate tool for research on malaria virulence.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria 08 Faculty of Science > Department of Biology > Institute of Cell Biology 09 Interdisciplinary Units > Microscopy Imaging Center (MIC) |
UniBE Contributor: |
De Niz Hidalgo, Mariana Isabel, Heussler, Volker |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
2041-1723 |
Publisher: |
Nature Publishing Group |
Funders: |
[4] Swiss National Science Foundation ; [81] Evimalar |
Language: |
English |
Submitter: |
Volker Heussler |
Date Deposited: |
01 Jun 2016 14:37 |
Last Modified: |
05 Dec 2022 14:56 |
Publisher DOI: |
10.1038/ncomms11659 |
PubMed ID: |
27225796 |
BORIS DOI: |
10.7892/boris.83472 |
URI: |
https://boris.unibe.ch/id/eprint/83472 |
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