Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects

Kieninger, Elisabeth; Singer, Florian; Fuchs, Oliver; Abbas, Chiara; Frey, Urs; Regamey, Nicolas; Casaulta, Carmen; Latzin, Philipp (2011). Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects. Journal of cystic fibrosis, 10(6), pp. 487-490. Amsterdam: Elsevier 10.1016/j.jcf.2011.07.006

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Multiple breath washout (MBW) measurements have recently been shown to be sensitive for detection of early cystic fibrosis (CF) lung disease, with the lung clearance index (LCI) being the most common measure for ventilation inhomogeneity. The aim of this observational study was to describe the longitudinal course of LCI from time of clinical diagnosis during infancy to school-age in eleven children with CF. Elevated LCI during infancy was present in seven subjects, especially in those with later clinical diagnosis. Tracking of LCI at follow-up was evident only in the four most severe cases. We provide the first longitudinal data describing the long-term course of LCI in a small group of infants with CF. Our findings support the clinical usefulness of MBW measurements to detect and monitor early lung disease in children with CF already present shortly after clinical diagnosis.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
UniBE Contributor:	Kieninger, Elisabeth, Singer, Florian, Fuchs, Oliver, Abbas, Chiara Carolina, Frey, Urs Peter, Regamey, Nicolas, Casaulta, Carmen, Latzin, Philipp
ISSN:	1569-1993
Publisher:	Elsevier
Language:	English
Submitter:	Anette van Dorland
Date Deposited:	04 Oct 2013 14:24
Last Modified:	02 Mar 2023 23:20
Publisher DOI:	10.1016/j.jcf.2011.07.006
PubMed ID:	21835702
Web of Science ID:	000298125400017
URI:	https://boris.unibe.ch/id/eprint/8364 (FactScience: 213890)