Detection of Astrovirus in Historical Cases of European Sporadic Bovine Encephalitis, Switzerland 1958–1976

Selimovic-Hamza, Senija; Bouzalas, Ilias; Vandevelde, Marc; Oevermann, Anna; Seuberlich, Torsten (2016). Detection of Astrovirus in Historical Cases of European Sporadic Bovine Encephalitis, Switzerland 1958–1976. Frontiers in veterinary science, 3, p. 91. Frontiers Media 10.3389/fvets.2016.00091

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European sporadic bovine encephalitis is a frequent diagnosis in neurologically diseased cattle, but its etiology remained unresolved. Using in situ hybridization, we have detected a recently discovered neurotropic bovine astrovirus in historical tissues in a high proportion of brain samples of affected cattle. Our results suggest that astroviruses were already involved in the pathogenesis of the disease several decades ago, but have gone undetected.

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