Refining the definition of hypereosinophilic syndrome

Simon, Hans-Uwe; Rothenberg, Marc E; Bochner, Bruce S; Weller, Peter F; Wardlaw, Andrew J; Wechsler, Michael E; Rosenwasser, Lanny J; Roufosse, Florence; Gleich, Gerald J; Klion, Amy D (2010). Refining the definition of hypereosinophilic syndrome. Journal of allergy and clinical immunology, 126(1), pp. 45-9. St. Louis, Mo.: Mosby 10.1016/j.jaci.2010.03.042

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Because of advances in our understanding of the hypereosinophilic syndrome (HES) and the availability of novel therapeutic agents, the original criteria defining these disorders are becoming increasingly problematic. Here, we discuss shortcomings with the current definition of HES and recent developments in the classification of these disorders. Despite significant progress in our understanding of the pathogenesis of some forms of HES, the current state of knowledge is still insufficient to formulate a new comprehensive etiologic definition of HESs. Nevertheless, we suggest a new working definition that overcomes some of the most obvious limitations with the original definition.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
UniBE Contributor:	Simon, Hans-Uwe
ISSN:	0091-6749
Publisher:	Mosby
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:09
Last Modified:	05 Dec 2022 14:00
Publisher DOI:	10.1016/j.jaci.2010.03.042
PubMed ID:	20639008
Web of Science ID:	000280061800009
URI:	https://boris.unibe.ch/id/eprint/894 (FactScience: 201188)