Balistreri, Giuseppe; Bognanni, Claudia; Mühlemann, Oliver (2017). Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay. Viruses, 9(1) Molecular Diversity Preservation International MDPI 10.3390/v9010024
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Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses. As for every other antiviral immune system, there is also evidence of viruses interfering with and modulating NMD to their own advantage. This review will discuss our current understanding of why and how NMD targets viral RNAs, and elaborate counter-defense strategies viruses utilize to escape NMD.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Bognanni, Claudia, Mühlemann, Oliver |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1999-4915 |
Publisher: |
Molecular Diversity Preservation International MDPI |
Language: |
English |
Submitter: |
Christina Schüpbach |
Date Deposited: |
08 Feb 2017 10:52 |
Last Modified: |
05 Dec 2022 15:02 |
Publisher DOI: |
10.3390/v9010024 |
PubMed ID: |
28124995 |
BORIS DOI: |
10.7892/boris.94718 |
URI: |
https://boris.unibe.ch/id/eprint/94718 |
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