Müller, Joachim; Hemphill, Andrew (2016). Drug target identification in protozoan parasites. Expert opinion on drug discovery, 11(8), pp. 815-824. Taylor & Francis 10.1080/17460441.2016.1195945
Full text not available from this repository. (Request a copy)INTRODUCTION
Despite the fact that diseases caused by protozoan parasites represent serious challenges for public health, animal production and welfare, only a limited panel of drugs has been marketed for clinical applications.
AREAS COVERED
Herein, the authors investigate two strategies, namely whole organism screening and target-based drug design. The present pharmacopoeia has resulted from whole organism screening, and the mode of action and targets of selected drugs are discussed. However, the more recent extensive genome sequencing efforts and the development of dry and wet lab genomics and proteomics that allow high-throughput screening of interactions between micromolecules and recombinant proteins has resulted in target-based drug design as the predominant focus in anti-parasitic drug development. Selected examples of target-based drug design studies are presented, and calcium-dependent protein kinases, important drug targets in apicomplexan parasites, are discussed in more detail.
EXPERT OPINION
Despite the enormous efforts in target-based drug development, this approach has not yet generated market-ready antiprotozoal drugs. However, whole-organism screening approaches, comprising of both in vitro and in vivo investigations, should not be disregarded. The repurposing of already approved and marketed drugs could be a suitable strategy to avoid fastidious approval procedures, especially in the case of neglected or veterinary parasitoses.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Müller, Heinz Joachim, Hemphill, Andrew |
Subjects: |
600 Technology > 630 Agriculture 500 Science > 570 Life sciences; biology |
ISSN: |
1746-045X |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Andrew Hemphill |
Date Deposited: |
24 Jul 2017 09:40 |
Last Modified: |
02 Mar 2023 23:29 |
Publisher DOI: |
10.1080/17460441.2016.1195945 |
PubMed ID: |
27238605 |
Uncontrolled Keywords: |
Apicomplexa drug design kinetoplastida mode of action repurposing target |
URI: |
https://boris.unibe.ch/id/eprint/96637 |
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