Heim, Markus H

Lett, Martin J; Mehta, Hema; Keogh, Adrian; Jaeger, Tina; Jacquet, Maxime; Powell, Kate; Meier, Marie-Anne; Fofana, Isabel; Melhem, Hassan; Vosbeck, Jürg; Cathomas, Gieri; Heigl, Andres; Heim, Markus H; Burri, Emanuel; Mertz, Kirsten D; Niess, Jan Hendrik; Kollmar, Otto; Zech, Christoph J; Ivanek, Robert; Duthaler, Urs; ... (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells. Gut, 71(12), pp. 2526-2538. BMJ Publishing Group 10.1136/gutjnl-2021-324478

Park, Sujin; Mossmann, Dirk; Chen, Qian; Wang, Xueya; Dazert, Eva; Colombi, Marco; Schmidt, Alexander; Ryback, Brendan; Ng, Charlotte K Y; Terracciano, Luigi M; Heim, Markus H; Hall, Michael N (2022). Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Molecular cell, 82(22), pp. 4246-4261. Cell Press 10.1016/j.molcel.2022.10.027

Suter, Polina; Dazert, Eva; Kuipers, Jack; Ng, Charlotte K Y; Boldanova, Tuyana; Hall, Michael N; Heim, Markus H; Beerenwinkel, Niko (2022). Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model. PLoS computational biology, 18(9), e1009767. Public Library of Science 10.1371/journal.pcbi.1009767

Ng, Charlotte K Y; Dazert, Eva; Boldanova, Tuyana; Coto-Llerena, Mairene; Nuciforo, Sandro; Ercan, Caner; Suslov, Aleksei; Meier, Marie-Anne; Bock, Thomas; Schmidt, Alexander; Ketterer, Sylvia; Wang, Xueya; Wieland, Stefan; Matter, Matthias S; Colombi, Marco; Piscuoglio, Salvatore; Terracciano, Luigi M; Hall, Michael N; Heim, Markus H (2022). Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages. Nature Communications, 13(1), p. 2436. Springer Nature 10.1038/s41467-022-29960-8

Gallon, John; Coto-Llerena, Mairene; Ercan, Caner; Bianco, Gaia; Paradiso, Viola; Nuciforo, Sandro; Taha-Melitz, Stephanie; Meier, Marie-Anne; Boldanova, Tujana; Pérez-Del-Pulgar, Sofía; Rodríguez-Tajes, Sergio; von Flüe, Markus; Soysal, Savas D; Kollmar, Otto; Llovet, Josep M; Villanueva, Augusto; Terracciano, Luigi M; Heim, Markus H; Ng, Charlotte K. Y. and Piscuoglio, Salvatore (2022). Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma. Molecular oncology, 16(3), pp. 665-682. Wiley 10.1002/1878-0261.13154

Ercan, Caner; Coto-Llerena, Mairene; Gallon, John; Fourie, Lana; Marinucci, Mattia; Hess, Gabriel F; Vosbeck, Jürg; Taha-Mehlitz, Stephanie; Boldanova, Tuyana; Meier, Marie-Anne; Tzankov, Alexandar; Matter, Matthias S; Hoffmann, Martin H K; Di Tommaso, Luca; von Flüe, Markus; Ng, Charlotte K. Y.; Heim, Markus H; Soysal, Savas D; Terracciano, Luigi M; Kollmar, Otto; ... (2022). Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report. Communications medicine, 2, p. 11. Springer Nature 10.1038/s43856-022-00074-y

Chen, Qian; Coto-Llerena, Mairene; Suslov, Aleksei; Teixeira, Raphael Dias; Fofana, Isabel; Nuciforo, Sandro; Hofmann, Maike; Thimme, Robert; Hensel, Nina; Lohmann, Volker; Ng, Charlotte K Y; Rosenberger, George; Wieland, Stefan; Heim, Markus H (2021). Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses. Nature Communications, 12(1), p. 4882. Springer Nature 10.1038/s41467-021-25218-x

Blumer, Tanja; Fofana, Isabel; Matter, Matthias S; Wang, Xueya; Montazeri, Hesam; Calabrese, Diego; Coto-Llerena, Mairene; Boldanova, Tujana; Nuciforo, Sandro; Kancherla, Venkatesh; Tornillo, Luigi; Piscuoglio, Salvatore; Wieland, Stefan; Terracciano, Luigi M; Ng, Kiu Yan Charlotte; Heim, Markus H (2019). Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors. Hepatology communications, 3(7), pp. 971-986. Wiley 10.1002/hep4.1365

Gauthiez, Emeline; Habfast-Robertson, Ines; Rüeger, Sina; Kutalik, Zoltan; Aubert, Vincent; Berg, Thomas; Cerny, Andreas; Gorgievski, Meri; George, Jacob; Heim, Markus H; Malinverni, Raffaele; Moradpour, Darius; Müllhaupt, Beat; Negro, Francesco; Semela, David; Semmo, Nasser; Villard, Jean; Bibert, Stéphanie; Bochud, Pierre-Yves (2017). A systematic review and meta-analysis of HCV clearance. Liver international, 37(10), pp. 1431-1445. Wiley 10.1111/liv.13401

Terczyńska-Dyla, Ewa; Bibert, Stephanie; Duong, Francois H T; Krol, Ilona; Jørgensen, Sanne; Collinet, Emilie; Kutalik, Zoltán; Aubert, Vincent; Cerny, Andreas; Kaiser, Laurent; Malinverni, Raffaele; Mangia, Alessandra; Moradpour, Darius; Müllhaupt, Beat; Negro, Francesco; Santoro, Rosanna; Semela, David; Semmo, Nasser; Heim, Markus H; Bochud, Pierre-Yves; ... (2015). Corrigendum: reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes. Nature communications, 6, p. 7280. Nature Publishing Group 10.1038/ncomms8280

Rothweiler, Sonja; Dill, Michael T; Terracciano, Luigi; Makowska, Zuzanna; Quagliata, Luca; Hlushchuk, Ruslan; Djonov, Valentin; Heim, Markus H; Semela, David (2014). Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model. Laboratory investigation, 95(3), pp. 351-362. Nature Publishing Group 10.1038/labinvest.2014.141

Balmer, Maria Luisa; Slack, Emma; De Gottardi, Andrea; Lawson, Melissa; Hapfelmeier, Siegfried Hektor; Miele, Luca; Grieco, Antonio; Van Vlierberghe, Hans; Fahrner, René; Patuto, Nicola; Bernsmeier, Christine; Ronchi, Francesca; Wyss, Madeleine; Keogh-Stroka, Deborah M.; Dickgreber, Nina; Heim, Markus H; McCoy, Kathy D; Macpherson, Andrew (2014). The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota. Science translational medicine, 6(237), 237ra66. American Association for the Advancement of Science 10.1126/scitranslmed.3008618

Bochud, Pierre-Yves; Bibert, Stéphanie; Kutalik, Zoltán; Patin, Etienne; Guergnon, Julien; Nalpas, Bertrand; Goossens, Nicolas; Kuske, Lorenz; Müllhaupt, Beat; Gerlach, Tillman; Heim, Markus H; Moradpour, Darius; Cerny, Andreas; Malinverni, Raffaele; Regenass, Stephan; Dollenmaier, Guenter; Hirsch, Hans; Martinetti, Gladys; Gorgiewski, Meri; Bourlière, Marc; ... (2012). IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes. Hepatology, 55(2), pp. 384-94. Hoboken, N.J.: Wiley Interscience 10.1002/hep.24678

Dill, Michael T; Rothweiler, Sonja; Djonov, Valentin; Hlushchuk, Ruslan; Tornillo, Luigi; Terracciano, Luigi; Meili-Butz, Silvia; Radtke, Freddy; Heim, Markus H; Semela, David (2012). Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice. Gastroenterology, 142(4), 967-977.e2. Philadelphia, Pa.: Elsevier 10.1053/j.gastro.2011.12.052

Kuske, Lorenz; Mensen, Armand; Müllhaupt, Beat; Negro, Francesco; Semela, David; Moradpour, Darius; Malé, Pierre Jean; Heim, Markus H; Malinverni, Raffaele; Cerny, Andreas; Dufour, Jean-François; Swiss Hepatitis C Cohort Study, (2012). Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma. Swiss medical weekly, 142, w13651. Muttenz: EMH Schweizerischer Ärzteverlag 10.4414/smw.2012.13651

Patin, Etienne; Kutalik, Zoltán; Guergnon, Julien; Bibert, Stéphanie; Nalpas, Bertrand; Jouanguy, Emmanuelle; Munteanu, Mona; Bousquet, Laurence; Argiro, Laurent; Halfon, Philippe; Boland, Anne; Müllhaupt, Beat; Semela, David; Dufour, Jean-François; Heim, Markus H; Moradpour, Darius; Cerny, Andreas; Malinverni, Raffaele; Hirsch, Hans; Martinetti, Gladys; ... (2012). Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. Gastroenterology, 143(5), 1244-52.e1-12. Philadelphia, Pa.: Elsevier 10.1053/j.gastro.2012.07.097

Lange, Christian M; Bibert, Stephanie; Kutalik, Zoltan; Burgisser, Philippe; Cerny, Andreas; Dufour, Jean-François; Geier, Andreas; Gerlach, Tilman J; Heim, Markus H; Malinverni, Raffaele; Negro, Francesco; Regenass, Stephan; Badenhoop, Klaus; Bojunga, Jörg; Sarrazin, Christoph; Zeuzem, Stefan; Müller, Tobias; Berg, Thomas; Bochud, Pierre-Yves; Moradpour, Darius; ... (2012). A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C. PLoS ONE, 7(7), e40159. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0040159

Lange, Christian M; Kutalik, Zoltan; Morikawa, Kenichi; Bibert, Stéphanie; Cerny, Andreas; Dollenmaier, Günter; Dufour, Jean-François; Gerlach, Tilman J; Heim, Markus H; Malinverni, Raffaele; Müllhaupt, Beat; Negro, Francesco; Moradpour, Darius; Bochud, Pierre-Yves; Swiss Hepatitis C Cohort Study Group, (2012). Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. Hepatology, 55(4), pp. 1038-47. Hoboken, N.J.: Wiley Interscience 10.1002/hep.24787

Dufour, Jean-François; Hoppe, Hanno; Heim, Markus H; Helbling, Beat; Maurhofer, Olivier; Szucs-Farkas, Zsolt; Kickuth, Ralph; Borner, Markus; Candinas, Daniel; Saar, Bettina (2010). Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: results of a phase I study. Oncologist, 15(11), pp. 1198-204. Miamisburg, Ohio: AlphaMed Press 10.1634/theoncologist.2010-0180