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Zimmer, Kai; Kocher, Florian; Untergasser, Gerold; Kircher, Brigitte; Amann, Arno; Baca, Yasmine; Xiu, Joanne; Korn, W Micheal; Berger, Martin D; Lenz, Heinz-Josef; Puccini, Alberto; Fontana, Elisa; Shields, Anthony F; Marshall, John L; Hall, Michael; El-Deiry, Wafik S; Hsiehchen, David; Macarulla, Teresa; Tabernero, Josep; Pichler, Renate; ... (2023). PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system. NPJ precision oncology, 7(1), p. 64. Springer Nature 10.1038/s41698-023-00409-5
Puccini, Alberto; Poorman, Kelsey; Catalano, Fabio; Seeber, Andreas; Goldberg, Richard M; Salem, Mohamed E; Shields, Anthony F; Berger, Martin D; Battaglin, Francesca; Tokunaga, Ryuma; Naseem, Madiha; Zhang, Wu; Philip, Philip A; Marshall, John L; Korn, W Michael; Lenz, Heinz-Josef (2022). Molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon reveals potential new therapeutic targets. Oncogene, 41(26), pp. 3455-3460. Springer Nature 10.1038/s41388-022-02350-6
Seeber, Andreas; Battaglin, Francesca; Zimmer, Kai; Kocher, Florian; Baca, Yasmine; Xiu, Joanne; Spizzo, Gilbert; Novotny-Diermayr, Veronica; Rieder, Dietmar; Puccini, Alberto; Swensen, Jeffrey; Ellis, Michelle; Goldberg, Richard M; Grothey, Axel; Shields, Anthony F; Marshall, John L; Weinberg, Benjamin A; Sackstein, Paul E; Hon Lim, Kiat; San Tan, Gek; ... (2022). Comprehensive analysis of R-spondin fusions and RNF43 mutations implicate novel therapeutic options in colorectal cancer. Clinical cancer research, 28(9), pp. 1863-1870. American Association for Cancer Research 10.1158/1078-0432.CCR-21-3018
Puccini, Alberto; Seeber, Andreas; Xiu, Joanne; Goldberg, Richard M; Soldato, Davide; Grothey, Axel; Shields, Anthony F; Salem, Mohamed E; Battaglin, Francesca; Berger, Martin Dave; El-Deiry, Wafik S; Tokunaga, Ryuma; Naseem, Madiha; Zhang, Wu; Arora, Sukeshi Patel; Khushman, Moh'd M; Hall, Michael J; Philip, Philip A; Marshall, John L; Korn, W Michael; ... (2021). Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients. NPJ precision oncology, 5(1), p. 95. Springer Nature 10.1038/s41698-021-00230-y
Naseem, Madiha; Cao, Shu; Yang, Dongyun; Millstein, Joshua; Puccini, Alberto; Loupakis, Fotios; Stintzing, Sebastian; Cremolini, Chiara; Tokunaga, Ryuma; Battaglin, Francesca; Soni, Shivani; Berger, Martin D.; Barzi, Afsaneh; Zhang, Wu; Falcone, Alfredo; Heinemann, Volker; Lenz, Heinz-Josef (2021). Random survival forests identify pathways with polymorphisms predictive of survival in KRAS mutant and KRAS wild-type metastatic colorectal cancer patients. Scientific reports, 11(1), p. 12191. Springer Nature 10.1038/s41598-021-91330-z
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu; Zhang, Wu; Cremolini, Chiara; Lonardi, Sara; Okazaki, Satoshi; Berger, Martin D.; Miyamoto, Yuji; Soni, Shivani; Barzi, Afsaneh; Yamaguchi, Toshiharu; Loupakis, Fotios; Falcone, Alfredo; Lenz, Heinz-Josef (2021). Clinical significance of enterocyte-specific gene polymorphisms as candidate markers of oxaliplatin-based treatment for metastatic colorectal cancer. The pharmacogenomics journal, 21(3), pp. 285-295. Springer Nature 10.1038/s41397-021-00207-x
Suenaga, Mitsukuni; Zhang, W U; Mashima, Tetsuo; Schirripa, Marta; Cao, Shu; Okazaki, Satoshi; Berger, Martin D.; Miyamoto, Yuji; Barzi, Afsaneh; Yamaguchi, Toshiharu; Lenz, Heinz-Josef (2021). Potential Molecular Cross Talk Among CCR5 Pathway Predicts Regorafenib Responsiveness in Metastatic Colorectal Cancer Patients. Cancer genomics & proteomics, 18(3), pp. 317-324. International Institute of Anticancer Research 10.21873/cgp.20262
Suenaga, Mitsukuni; Cao, Shu; Zhang, Wu; Matsusaka, Satoshi; Okazaki, Satoshi; Berger, Martin D.; Miyamoto, Yuji; Schirripa, Marta; Barzi, Afsaneh; Yamamoto, Noriko; Yamaguchi, Toshiharu; Lenz, Heinz-Josef (2021). Role of enterocyte-specific gene polymorphisms in response to adjuvant treatment for stage III colorectal cancer. Pharmacogenetics and genomics, 31(1), pp. 10-16. Lippincott Williams & Wilkins 10.1097/FPC.0000000000000416
Puccini, Alberto; Poorman, Kelsey; Salem, Mohamed E; Soldato, Davide; Seeber, Andreas; Goldberg, Richard M; Shields, Anthony F; Xiu, Joanne; Battaglin, Francesca; Berger, Martin D.; Tokunaga, Ryuma; Naseem, Madiha; Barzi, Afsaneh; Iqbal, Syma; Zhang, Wu; Soni, Shivani; Hwang, Jimmy J; Philip, Philip A; Sciallero, Stefania; Korn, W Michael; ... (2020). Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs). Clinical cancer research, 26(22), pp. 5943-5951. American Association for Cancer Research 10.1158/1078-0432.CCR-20-1804
Tokunaga, Ryuma; Xiu, Joanne; Goldberg, Richard M; Philip, Philip A; Seeber, Andreas; Battaglin, Francesca; Arai, Hiroyuki; Lo, Jae Ho; Naseem, Madiha; Puccini, Alberto; Berger, Martin D.; Soni, Shivani; Zhang, Wu; Chen, Sting; Hwang, Jimmy J; Shields, Anthony F; Marshall, John L; Baba, Hideo; Korn, W Michael and Lenz, Heinz-Josef (2020). The impact of ARID1A mutation on molecular characteristics in colorectal cancer. European journal of cancer, 140, pp. 119-129. Elsevier 10.1016/j.ejca.2020.09.006
Volz, Nico B; Hanna, Diana L; Stintzing, Sebastian; Zhang, Wu; Yang, Dongyun; Cao, Shu; Ning, Yan; Matsusaka, Satoshi; Sunakawa, Yu; Berger, Martin D.; Cremolini, Chiara; Loupakis, Fotios; Falcone, Alfredo; Lenz, Heinz-Josef (2020). Polymorphisms within Immune Regulatory Pathways Predict Cetuximab Efficacy and Survival in Metastatic Colorectal Cancer Patients. Cancers, 12(10) MDPI AG 10.3390/cancers12102947
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu; Zhang, Wu; Yang, Dongyun; Cremolini, Chiara; Murgioni, Sabina; Lonardi, Sara; Ning, Yan; Okazaki, Satoshi; Berger, Martin D.; Miyamoto, Yuji; Barzi, Afsaneh; Loupakis, Fotios; Falcone, Alfredo; Lenz, Heinz-Josef (2020). Single Nucleotide Polymorphisms in MiRNA Binding Sites of Nucleotide Excision Repair-Related Genes Predict Clinical Benefit of Oxaliplatin in FOLFOXIRI Plus Bevacizumab: Analysis of the TRIBE Trial. Cancers, 12(7) MDPI AG 10.3390/cancers12071742
Berger, Martin D.; Ning, Yan; Stintzing, Sebastian; Heinemann, Volker; Cao, Shu; Zhang, Wu; Yang, Dongyun; Miyamoto, Yuji; Suenaga, Mitsukuni; Schirripa, Marta; Hanna, Diana L; Soni, Shivani; Puccini, Alberto; Tokunaga, Ryuma; Naseem, Madiha; Battaglin, Francesca; Cremolini, Chiara; Falcone, Alfredo; Loupakis, Fotios and Lenz, Heinz-Josef (2020). A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: data from FIRE-3 and TRIBE trials. European journal of cancer, 131, pp. 89-97. Elsevier 10.1016/j.ejca.2020.02.048
Matsusaka, Satoshi; Hanna, Diana L; Ning, Yan; Yang, Dongyun; Cao, Shu; Berger, Martin D.; Miyamoto, Yuji; Suenaga, Mitsukuni; Dan, Shingo; Mashima, Tetsuo; Seimiya, Hiroyuki; Zhang, Wu; Lenz, Heinz-Josef (2020). Epidermal growth factor receptor mRNA expression: A potential molecular escape mechanism from regorafenib. Cancer science, 111(2), pp. 441-450. Wiley 10.1111/cas.14273
Miyamoto, Yuji; Schirripa, Marta; Suenaga, Mitsukuni; Cao, Shu; Zhang, Wu; Okazaki, Satoshi; Berger, Martin D.; Matsusaka, Satoshi; Yang, Dongyun; Ning, Yan; Baba, Hideo; Loupakis, Fotios; Lonardi, Sara; Pietrantonio, Filippo; Borelli, Beatrice; Cremolini, Chiara; Yamaguchi, Toshiharu; Lenz, Heinz-Josef (2020). A polymorphism in the cachexia-associated gene INHBA predicts efficacy of regorafenib in patients with refractory metastatic colorectal cancer. PLoS ONE, 15(9), e0239439. Public Library of Science 10.1371/journal.pone.0239439
Suenaga, Mitsukuni; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Okazaki, Satoshi; Berger, Martin Dave; Miyamoto, Yuji; Schirripa, Marta; Soni, Shivani; Barzi, Afsaneh; Yamaguchi, Toshiharu; Lenz, Heinz-Josef (2019). Genetic variants in CCL5 and CCR5 genes and serum VEGF-A levels predict efficacy of bevacizumab in metastatic colorectal cancer patients. International journal of cancer, 144(10), pp. 2567-2577. Wiley-Blackwell 10.1002/ijc.31968
Tokunaga, Ryuma; Xiu, Joanne; Johnston, Curtis; Goldberg, Richard M; Philip, Philip A; Seeber, Andreas; Naseem, Madiha; Lo, Jae Ho; Arai, Hiroyuki; Battaglin, Francesca; Puccini, Alberto; Berger, Martin D.; Soni, Shivani; Zhang, Wu; Hwang, Jimmy J; Shields, Anthony F; Marshall, John L; Baba, Hideo; Korn, W Michael and Lenz, Heinz-Josef (2019). Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-sided and Left-sided Colorectal Cancer. Clinical cancer research, 25(10), pp. 3096-3103. American Association for Cancer Research 10.1158/1078-0432.CCR-18-3388
Tokunaga, Ryuma; Cao, Shu; Naseem, Madiha; Battaglin, Francesca; Lo, Jae Ho; Arai, Hiroyuki; Loupakis, Fotios; Stintzing, Sebastian; Puccini, Alberto; Berger, Martin D.; Soni, Shivani; Zhang, Wu; Mancao, Christoph; Salhia, Bodour; Mumenthaler, Shannon M; Weisenberger, Daniel J; Liang, Gangning; Cremolini, Chiara; Heinemann, Volker; Falcone, Alfredo; ... (2019). AMPK variant, a candidate of novel predictor for chemotherapy in metastatic colorectal cancer: A meta-analysis using TRIBE, MAVERICC and FIRE3. International journal of cancer, 145(8), pp. 2082-2090. Wiley-Blackwell 10.1002/ijc.32261
Tokunaga, Ryuma; Cao, Shu; Naseem, Madiha; Lo, Jae Ho; Battaglin, Francesca; Puccini, Alberto; Berger, Martin Dave; Soni, Shivani; Millstein, Joshua; Zhang, Wu; Stintzing, Sebastian; Loupakis, Fotios; Cremolini, Chiara; Heinemann, Volker; Falcone, Alfredo; Lenz, Heinz-Josef (2019). Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy. Clinical colorectal cancer, 18(1), e8-e19. Elsevier 10.1016/j.clcc.2018.09.003
Tokunaga, Ryuma; Naseem, Madiha; Lo, Jae Ho; Battaglin, Francesca; Soni, Shivani; Puccini, Alberto; Berger, Martin Dave; Zhang, Wu; Baba, Hideo; Lenz, Heinz-Josef (2019). B cell and B cell-related pathways for novel cancer treatments. Cancer treatment reviews, 73, pp. 10-19. Elsevier 10.1016/j.ctrv.2018.12.001
Suenaga, Mitsukuni; Stintzing, Sebastian; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Okazaki, Satoshi; Berger, Martin Dave; Miyamoto, Yuji; Schirripa, Marta; Soni, Shivani; Barzi, Afsaneh; Heinemann, Volker; Lenz, Heinz-Josef (2019). Role of CCL5 and CCR5 gene polymorphisms in epidermal growth factor receptor signalling blockade in metastatic colorectal cancer: analysis of the FIRE-3 trial. European journal of cancer, 107, pp. 100-114. Elsevier 10.1016/j.ejca.2018.11.019
Stanczak, Michal A; Siddiqui, Shoib S; Trefny, Marcel P; Thommen, Daniela S; Frias Boligan, Kayluz; von Gunten, Stephan; Tzankov, Alexandar; Tietze, Lothar; Lardinois, Didier; Heinzelmann-Schwarz, Viola; von Bergwelt-Baildon, Michael S; Zhang, Wu; Lenz, Heinz-Josef; Han, Younghan; Amos, Christopher I; Syedbasha, Mohammedyaseen; Egli, Adrian; Stenner, Frank; Speiser, Daniel E; Varki, Ajit; ... (2018). Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells. Journal of clinical investigation, 128(11), pp. 4912-4923. American Society for Clinical Investigation 10.1172/JCI120612
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu; Zhang, Wu; Yang, Dongyun; Cremolini, Chiara; Lonardi, Sara; Bergamo, Francesca; Ning, Yang; Yamamoto, Noriko; Okazaki, Satoshi; Berger, Martin Dave; Miyamoto, Yuji; Gopez, Roel; Barzi, Afsaneh; Yamaguchi, Toshiharu; Stintzing, Sebastian; Heinemann, Volker; Loupakis, Fotios; Falcone, Alfredo; ... (2018). Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer. The pharmacogenomics journal, 18(5), pp. 623-632. Nature Publishing Group 10.1038/s41397-018-0030-8
Hanna, Diana L; Loupakis, Fotios; Yang, Dongyun; Cremolini, Chiara; Schirripa, Marta; Li, Meng; Matsusaka, Satoshi; Berger, Martin Dave; Miyamoto, Yuji; Zhang, Wu; Ning, Yan; Antoniotti, Carlotta; Salvatore, Lisa; Moran, Miriana; Zeger, Gary; Astrow, Stephanie H; Falcone, Alfredo; Lenz, Heinz-Josef (2018). Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study. Clinical colorectal cancer, 17(3), e471-e488. Elsevier 10.1016/j.clcc.2018.03.006
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Cremolini, Chiara; Antoniotti, Carlotta; Borelli, Beatrice; Mashima, Tetsuo; Okazaki, Satoshi; Berger, Martin Dave; Miyamoto, Yuji; Gopez, Roel; Barzi, Afsaneh; Lonardi, Sara; Yamaguchi, Toshiharu; Falcone, Alfredo; Loupakis, Fotios and Lenz, Heinz-Josef (2018). Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib. Clinical colorectal cancer, 17(2), e395-e414. Elsevier 10.1016/j.clcc.2018.02.010
Naseem, Madiha; Barzi, Afsaneh; Brezden-Masley, Christine; Puccini, Alberto; Berger, Martin Dave; Tokunaga, Ryuma; Battaglin, Francesca; Soni, Shivani; McSkane, Michelle; Zhang, Wu; Lenz, Heinz-Josef (2018). Outlooks on Epstein-Barr virus associated gastric cancer. Cancer treatment reviews, 66, pp. 15-22. Elsevier 10.1016/j.ctrv.2018.03.006
Berger, Martin Dave; Stintzing, Sebastian; Heinemann, Volker; Cao, Shu; Yang, Dongyun; Sunakawa, Yu; Matsusaka, Satoshi; Ning, Yan; Okazaki, Satoshi; Miyamoto, Yuji; Suenaga, Mitsukuni; Schirripa, Marta; Hanna, Diana L; Soni, Shivani; Puccini, Alberto; Zhang, Wu; Cremolini, Chiara; Falcone, Alfredo; Loupakis, Fotios and Lenz, Heinz-Josef (2018). A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab. Clinical cancer research, 24(4), pp. 784-793. American Association for Cancer Research 10.1158/1078-0432.CCR-17-1663
Tokunaga, Ryuma; Zhang, Wu; Naseem, Madiha; Puccini, Alberto; Berger, Martin Dave; Soni, Shivani; McSkane, Michelle; Baba, Hideo; Lenz, Heinz-Josef (2018). CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation - A target for novel cancer therapy. Cancer treatment reviews, 63, pp. 40-47. Elsevier 10.1016/j.ctrv.2017.11.007
Schirripa, Marta; Zhang, Wu; Yang, Dongyun; Cao, Shu; Okazaki, Satoshi; Loupakis, Fotios; Berger, Martin Dave; Ning, Yan; Miyamoto, Yuji; Suenaga, Mitsukuni; Alberti, Giulia; West, Jordan D; Lonardi, Sara; Khoukaz, Taline; Bergamo, Francesca; Battaglin, Francesca; Antoniotti, Carlotta; Falcone, Alfredo; Stintzing, Sebastian; Heinemann, Volker; ... (2018). NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients. PLoS ONE, 13(3), e0193640. Public Library of Science 10.1371/journal.pone.0193640
Puccini, Alberto; Berger, Martin Dave; Naseem, Madiha; Tokunaga, Ryuma; Battaglin, Francesca; Cao, Shu; Hanna, Diana L; McSkane, Michelle; Soni, Shivani; Zhang, Wu; Lenz, Heinz-Josef (2017). Colorectal cancer: epigenetic alterations and their clinical implications. Biochimica et biophysica acta, 1868(2), pp. 439-448. Elsevier 10.1016/j.bbcan.2017.09.003
Okazaki, Satoshi; Schirripa, Marta; Loupakis, Fotios; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Berger, Martin Dave; Miyamoto, Yuji; Suenaga, Mitsukuni; Iqubal, Syma; Barzi, Afsaneh; Cremolini, Chiara; Falcone, Alfredo; Battaglin, Francesca; Salvatore, Lisa; Borelli, Beatrice; Helentjaris, Timothy G; Lenz, Heinz-Josef (2017). Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Cancer, 123(22), pp. 4506-4514. John Wiley & Sons 10.1002/cncr.30880
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu; Zhang, Wu; Yang, Dongyun; Dadduzio, Vincenzo; Salvatore, Lisa; Borelli, Beatrice; Pietrantonio, Filippo; Ning, Yan; Okazaki, Satoshi; Berger, Martin Dave; Miyamoto, Yuji; Gopez, Roel; Barzi, Afsaneh; Yamaguchi, Toshiharu; Loupakis, Fotios; Lenz, Heinz-Josef (2017). Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer. European journal of cancer, 86, pp. 197-206. Elsevier 10.1016/j.ejca.2017.08.033
Okazaki, Satoshi; Stintzing, Sebastian; Sunakawa, Yu; Cao, Shu; Zhang, Wu; Yang, Dongyun; Ning, Yan; Matsusaka, Satoshi; Berger, Martin Dave; Miyamoto, Yuji; Suenaga, Mitsukuni; Schirripa, Marta; West, Jordan D; Gopez, Roel; Akihito, Tsuji; Ichikawa, Wataru; Heinemann, Volker; DePaolo, R William; Lenz, Heinz-Josef (2017). Predictive value of TLR7 polymorphism for cetuximab-based chemotherapy in patients with metastatic colorectal cancer. International journal of cancer, 141(6), pp. 1222-1230. Wiley-Blackwell 10.1002/ijc.30810
Schirripa, Marta; Zhang-Wu, Xiaxia; Heinemann, Volker; Cao, Shu; Okazaki, Satoshi; Yang, Dongyun; Loupakis, Fotios; Berger, Martin Dave; Ning, Yan; Miyamoto, Yuji; Suenaga, Mitsukuni; Gopez, Roel F; West, Jordan D; Hanna, Diana; Barzi, Afsaneh; Falcone, Alfredo; Stintzing, Sebastian; Lenz, Heinz-Josef (2017). Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial. International journal of cancer, 141(2), pp. 383-392. Wiley-Blackwell 10.1002/ijc.30715
Puccini, Alberto; Berger, Martin Dave; Zhang, Wu; Lenz, Heinz-Josef (2017). What We Know About Stage II and III Colon Cancer: It's Still Not Enough. Targeted oncology, 12(3), pp. 265-275. Springer 10.1007/s11523-017-0494-5
Berger, Martin Dave; Yamauchi, Shinichi; Cao, Shu; Hanna, Diana L; Sunakawa, Yu; Schirripa, Marta; Matsusaka, Satoshi; Yang, Dongyun; Groshen, Susan; Zhang, Wu; Ning, Yan; Okazaki, Satoshi; Miyamoto, Yuji; Suenaga, Mitsukuni; Lonardi, Sara; Cremolini, Chiara; Falcone, Alfredo; Heinemann, Volker; Loupakis, Fotios; Stintzing, Sebastian; ... (2017). Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials. European journal of cancer, 77, pp. 13-20. Elsevier 10.1016/j.ejca.2017.02.020
