Mäser, Pascal

Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio M; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer (2021). Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angewandte Chemie (International ed.), 60(28), pp. 15613-15621. Wiley-VCH 10.1002/anie.202102153

Schmidt, Remo S.; Pereira de Macêdo, Juan; Steinmann, Michael Eduard; González Salgado, Amaia; Bütikofer, Peter; Sigel, Erwin; Rentsch, Doris; Mäser, Pascal (2018). Transporters of Trypanosoma brucei -phylogeny, physiology, pharmacology. FEBS journal, 285(6), pp. 1012-1023. Wiley 10.1111/febs.14302

Steinmann, Michael E.; Schmidt, Remo S.; Pereira de Macêdo, Juan; Kunz Renggli, Christina; Bütikofer, Peter; Rentsch, Doris; Mäser, Pascal; Sigel, Erwin (2017). Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei. PLoS ONE, 12(12), pp. 1-18. Public Library of Science 10.1371/journal.pone.0188219

Steinmann, Michael Eduard; Schmidt, Remo S; Bütikofer, Peter; Mäser, Pascal; Sigel, Erwin (2017). TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes. Scientific Reports, 7(1), p. 656. Nature Publishing Group 10.1038/s41598-017-00752-1

Mathieu, Christoph; Pereira de Macêdo, Juan; Hürlimann, Daniel; Wirdnam, Corina; Haindrich, Alexander; Suter, Marianne; González Salgado, Amaia; Schmidt, Remo; Inbar, Ehud; Mäser, Pascal; Bütikofer, Peter; Zilberstein, Dan; Rentsch, Doris (2017). Arginine and Lysine Transporters Are Essential for Trypanosoma brucei. PLoS ONE, 12(1), e0168775. Public Library of Science 10.1371/journal.pone.0168775

Wenzler, Tanja; Schumann-Burkard, Gabriela; Schmidt, Remo S.; Mäser, Pascal; Bergner, Andreas; Roditi, Isabel; Brun, Reto (2016). A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes. Scientific Reports, 6(22451), p. 22451. Nature Publishing Group 10.1038/srep22451

Steinmann, Michael Eduard; González Salgado, Amaia; Bütikofer, Peter; Mäser, Pascal; Sigel, Erwin (2015). A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes. FASEB journal, 29(8), pp. 3228-3237. Federation of American Societies for Experimental Biology 10.1096/fj.15-271353

de Macêdo, Juan P.; Schumann-Burkard, Gabriela; Niemann, Moritz; Barrett, Michael P.; Vial, Henri; Mäser, Pascal; Roditi, Isabel; Schneider, André; Bütikofer, Peter; Horn, David (2015). An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei. PLoS pathogens, 11(5), e1004875. Public Library of Science 10.1371/journal.ppat.1004875

Shameer, Sanu; Logan-Klumpler, Flora J; Vinson, Florence; Cottret, Ludovic; Merlet, Benjamin; Achcar, Fiona; Boshart, Michael; Berriman, Matthew; Breitling, Rainer; Bringaud, Frédéric; Bütikofer, Peter; Cattanach, Amy M; Bannerman-Chukualim, Bridget; Creek, Darren J; Crouch, Kathryn; de Koning, Harry P; Denise, Hubert; Ebikeme, Charles; Fairlamb, Alan H; Ferguson, Michael A J; ... (2015). TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic acids research, 43(DBissue), D637-D644. Information Retrieval Ltd. 10.1093/nar/gku944

Mathieu, Christoph; González Salgado, Amaia; Wirdnam, Corina; Meier, Stefan; Suter, Marianne; Inbar, Ehud; Mäser, Pascal; Zilberstein, Dan; Sigel, Erwin; Bütikofer, Peter; Rentsch, Doris (2014). Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids. Biochemical journal, 463(1), pp. 9-18. Portland Press 10.1042/BJ20140719

Fügi, Matthias A; Gunasekera, Kapila; Ochsenreiter, Torsten; Guan, Xueli; Wenk, Markus R; Mäser, Pascal (2014). Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack. Journal of lipid research, 55(5), pp. 929-938. American Society for Biochemistry and Molecular Biology ASBMB 10.1194/jlr.M048017

Macêdo, Juan P.; Schmidt, Remo S.; Mäser, Pascal; Rentsch, Doris; Vial, Henri J.; Sigel, Erwin; Bütikofer, Peter (2013). Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms. Molecular and biochemical parasitology, 190(1), pp. 16-22. Amsterdam: Elsevier 10.1016/j.molbiopara.2013.05.007

Gonzalez-Salgado, Amaia; Steinmann, Michael E; Greganova, Eva; Rauch, Monika; Mäser, Pascal; Sigel, Erwin; Bütikofer, Peter (2012). myo-Inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei. Journal of biological chemistry, 287(16), pp. 13313-23. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.344812

Rufener, Lucien; Baur, Roland; Kaminsky, Ronald; Mäser, Pascal; Sigel, Erwin (2010). Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus. Molecular pharmacology, 78(5), pp. 895-902. Bethesda, Md.: American Society for Pharmacology and Experimental Therapeutics 10.1124/mol.110.066498

Rufener, Lucien; Keiser, Jennifer; Kaminsky, Ronald; Mäser, Pascal; Nilsson, Daniel (2010). Phylogenomics of ligand-gated ion channels predicts monepantel effect. PLoS pathogens, 6(9), e1001091. San Francisco, Calif.: Public Library of Science 10.1371/journal.ppat.1001091

Nerima, Barbara; Nilsson, Daniel; Mäser, Pascal (2010). Comparative genomics of metabolic networks of free-living and parasitic eukaryotes. BMC Genomics, 11(1), p. 217. London: BioMed Central 10.1186/1471-2164-11-217

Mosimann, Marc; Goshima, Shinobu; Wenzler, Tanja; Lüscher, Alexandra; Uozumi, Nobuyuki; Mäser, Pascal (2010). A Trk/HKT-type K+ transporter from Trypanosoma brucei. Eukaryotic cell, 9(4), pp. 539-546. Washington, D.C.: American Society for Microbiology ASM 10.1128/EC.00314-09

Pusnik, Mascha; Charrière, Fabien; Mäser, Pascal; Waller, Ross F.; Dagley, Michael J.; Lithgow, Trevor; Schneider, André (2009). The Single Mitochondrial Porin of Trypanosoma brucei is the Main Metabolite Transporter in the Outer Mitochondrial Membrane. Molecular Biology and Evolution, 26(3), pp. 671-680. Oxford: Oxford University Press 10.1093/molbev/msn288

Ward, John M.; Mäser, Pascal; Schroeder, Julian I. (2009). Plant ion channels: gene families, physiology, and functional genomics analyses. Annual review of physiology, 71(1), pp. 59-82. Palo Alto, Calif.: Annual Reviews Inc. 10.1146/annurev.physiol.010908.163204

Rufener, Lucien; Mäser, Pascal; Roditi, Isabel; Kaminsky, Ronald (2009). Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel. PLoS pathogens, 5(4), e1000380. San Francisco, Calif.: Public Library of Science 10.1371/journal.ppat.1000380

Rufener, Lucien; Kaminsky, Ronald; Mäser, Pascal (2009). In vitro selection of Haemonchus contortus for benzimidazole resistance reveals a mutation at amino acid 198 of beta-tubulin. Molecular and biochemical parasitology, 168(1), pp. 120-2. Amsterdam: Elsevier 10.1016/j.molbiopara.2009.07.002

Kuettel, Sabine; Mosimann, Marc; Mäser, Pascal; Kaiser, Marcel; Brun, Reto; Scapozza, Leonardo; Perozzo, Remo (2009). Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. PLoS neglected tropical diseases, 3(8), e506. San Francisco, Calif.: Public Library of Science 10.1371/journal.pntd.0000506

Kazibwe, Anne J.; Nerima, Barbara; de Koning, Harry P.; Mäser, Pascal; Barrett, Michael P.; Matovu, Enock (2009). Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. PLoS neglected tropical diseases, 3(9), e523. San Francisco, Calif.: Public Library of Science 10.1371/journal.pntd.0000523

Kaminsky, Ronald; Ducray, Pierre; Jung, Martin; Clover, Ralph; Rufener, Lucien; Bouvier, Jacques; Schorderet Weber, Sandra; Wenger, Andre; Wieland-Berghausen, Susanne; Goebel, Thomas; Gauvry, Noelle; Pautrat, François; Skripsky, Thomas; Froelich, Olivier; Komoin-Oka, Clarisse; Westlund, Bethany; Sluder, Ann; Mäser, Pascal (2008). A new class of anthelmintics effective against drug-resistant nematodes. Nature, 452(7184), pp. 176-180. London: Macmillan Journals Ltd. 10.1038/nature06722

Vodnala, Munender; Fijolek, Artur; Rofougaran, Reza; Mosimann, Marc; Mäser, Pascal; Hofer, Anders (2008). Adenosine Kinase Mediates High Affinity Adenosine Salvage in. Journal of biological chemistry, 283(9), pp. 5380-5388. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M705603200

Kwak, JM; Mäser, Pascal; Schroeder, JI (2008). The Clickable Guard Cell, Version II: Interactive Model of Guard Cell Signal Transduction Mechanisms and Pathways. Arabidopsis book, 6, e0114. Rockville, Md.: American Society of Plant Biologists 10.1199/tab.0114

Ghisi, Marc; Kaminsky, Robert; Mäser, Pascal (2007). Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes. Veterinary parasitology, 144(3-4), pp. 313-320. Amsterdam: Elsevier 10.1016/j.vetpar.2006.10.003

Al-Salabi, Mohammed; Wallace, Lynsey; Lüscher, Alexandra; Mäser, Pascal; Candlish, Denise; Rodenko, Boris; Gould, Matthew; Jabeen, Ishrat; Ajith, Sreekantan; de Koning, Harry (2007). Molecular interactions underlying the unusually high adenosine affinity of a novel Trypanosoma brucei nucleoside transporter. Molecular pharmacology, 71(3), pp. 921-929. Bethesda, Md.: American Society for Pharmacology and Experimental Therapeutics 10.1124/mol.106.031559

Bernhard, Sonja; Nerima, Barbara; Mäser, Pascal; Brun, Reto (2007). Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance. International journal for parasitology, 37(13), pp. 1443-8. Kidlington, UK: Elsevier 10.1016/j.ijpara.2007.05.007

Bridges, Daniel; Gould, Matthew; Nerima, Barbara; Mäser, Pascal; Burchmore, Richard; de Koning, Harry (2007). Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes. Molecular pharmacology, 71(4), pp. 1098-108. Bethesda, Md.: American Society for Pharmacology and Experimental Therapeutics 10.1124/mol.106.031351

Fankhauser, Niklaus; Nguyen-Ha, Tien-Minh; Adler, Joël; Mäser, Pascal (2007). Surface antigens and potential virulence factors from parasites detected by comparative genomics of perfect amino acid repeats. Proteome science, 5(December), p. 20. London: BioMed Central 10.1186/1477-5956-5-20

Gierth, Markus; Mäser, Pascal (2007). Potassium transporters in plants--involvement in K+ acquisition, redistribution and homeostasis. FEBS letters, 581(12), pp. 2348-56. Amsterdam: Elsevier 10.1016/j.febslet.2007.03.035

Lüscher, Alexandra; de Koning, Harry; Mäser, Pascal (2007). Chemotherapeutic strategies against Trypanosoma brucei: drug targets vs. drug targeting. Current pharmaceutical design, 13(6), pp. 555-67. Hilversum: Bentham Science Publishers 10.2174/138161207780162809

Lüscher, Alexandra; Önal, Pinar; Schweingruber, Anne-Marie; Mäser, Pascal (2007). Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites. Antimicrobial agents and chemotherapy, 51(11), pp. 3895-901. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00458-07

Maina, Naomi; Maina, Kagira Joseph; Mäser, Pascal; Brun, Reto (2007). Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate. Acta tropica, 104(2-3), pp. 84-90. Basel: Elsevier 10.1016/j.actatropica.2007.07.007

Maina, Naomi; Oberle, Michael; Otieno, Charles; Kunz, Christina; Mäser, Pascal; Ndung'u, Joseph; Brun, Reto (2007). Isolation and propagation of Trypanosoma brucei gambiense from sleeping sickness patients in south Sudan. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101(6), pp. 540-546. Amsterdam: Royal Society of Tropical Medicine and Hygiene 10.1016/j.trstmh.2006.11.008

Afework, Yohannes; Mäser, Pascal; Etschmann, Benjamin; Samson Himmelstjerna, Georg; Zessin, Karl-Hans; Clausen, Peter-Henning (2006). Rapid identification of isometamidium-resistant stocks of Trypanosoma b. brucei by PCR - RFLP. Parasitology research, 99(3), pp. 253-261. Berlin: Springer 10.1007/s00436-006-0141-z

Stoffel, Sabine; Rodenko, Boris; Schweingruber, Anne-Marie; Mäser, Pascal; de Koning, Harry; Schweingruber, Ernst (2006). Biosynthesis and uptake of thiamine (vitamin B1) in bloodstream from Trypanosoma brucei brucei and interference of the vitamin with melarsen oxide activity. International journal for parasitology, 36(2), pp. 229-236. Kidlington, UK: Elsevier 10.1016/j.ijpara.2005.10.003

Fankhauser, Niklaus; Mäser, Pascal (2005). Identification of GPI anchor attachment signals by a Kohonen self-organizing map. Bioinformatics, 21(9), pp. 1846-1852. Oxford University Press 10.1093/bioinformatics/bti299