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van der Spoel, Evie; van Vliet, Nicolien A; Poortvliet, Rosalinde K E; Du Puy, Robert S; den Elzen, Wendy P J; Quinn, Terence J; Stott, David J; Sattar, Naveed; Kearney, Patricia M; Blum, Manuel R; Alwan, Heba; Rodondi, Nicolas; Collet, Tinh-Hai; Westendorp, Rudi G J; Ballieux, Bart E; Jukema, J Wouter; Dekkers, Olaf M; Gussekloo, Jacobijn; Mooijaart, Simon P and van Heemst, Diana (2024). Incidence and determinants of spontaneous normalization of subclinical hypothyroidism in older adults. The journal of clinical endocrinology and metabolism, 109(3), e1167-e1174. Oxford University Press 10.1210/clinem/dgad623
Du Puy, Robert S; Poortvliet, Rosalinde K E; Mooijaart, Simon P; Stott, David J; Quinn, Terry; Sattar, Naveed; Westendorp, Rudi G J; Kearney, Patricia M; McCarthy, Vera J C; Byrne, Stephen; Rodondi, Nicolas; Baretella, Oliver; Collet, Tinh-Hai; van Heemst, Diana; Dekkers, Olaf M; Jukema, J Wouter; Smit, Johannes W A; Gussekloo, Jacobijn; den Elzen, Wendy P J (2022). No effect of levothyroxine on hemoglobin in older adults with subclinical hypothyroidism: pooled results from two RCTs. Journal of clinical endocrinology and metabolism, 107(6), e2339-e2347. Endocrine Society 10.1210/clinem/dgac106
Zijlstra, Laurien E; Jukema, J Wouter; Westendorp, Rudi G J; Du Puy, Robert S; Poortvliet, Rosalinde K E; Kearney, Patricia M; O'Keeffe, Linda; Dekkers, Olaf M; Blum, Manuel R.; Rodondi, Nicolas; Collet, Tinh-Hai; Quinn, Terence J; Sattar, Naveed; Stott, David J; Trompet, Stella; den Elzen, Wendy P J; Gussekloo, Jacobijn; Mooijaart, Simon P (2021). Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials. Frontiers in endocrinology, 12, p. 674841. Frontiers Research Foundation 10.3389/fendo.2021.674841
Stuber, Mirah J.; Moutzouri, Elisavet; Feller, Martin; Del Giovane, Cinzia; Bauer, Douglas C; Blum, Manuel R.; Collet, Tinh-Hai; Gussekloo, Jacobijn; Mooijaart, Simon P; McCarthy, Vera J C; Aujesky, Drahomir; Westendorp, Rudi; Stott, David J; Glynn, Nancy W; Kearney, Patricia M; Rodondi, Nicolas (2020). Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial. Journals of gerontology. Series A - biological sciences and medical sciences, 75(9), e89-e94. Oxford University Press 10.1093/gerona/glaa123
Gencer, Baris; Moutzouri, Elisavet; Blum, Manuel; Feller, Martin; Collet, Tinh-Hai; Del Giovane, Cinzia; Da Costa, Bruno R.; Buffle, Eric; Monney, Pierre; Gabus, Vincent; Müller, Hajo; Sykiotis, Gerasimos P; Kearney, Patricia; Gussekloo, Jacobijn; Westendorp, Rudi; Stott, David J; Bauer, Douglas C; Rodondi, Nicolas (2020). The Impact of Levothyroxine on Cardiac Function in Older Adults with Mild Subclinical Hypothyroidism: a Randomized Clinical Trial. American journal of medicine, 133(7), 848-856.e5. Elsevier 10.1016/j.amjmed.2020.01.018
de Montmollin, Maria Karolina; Feller, Martin; Beglinger, Shanthi; McConnachie, Alex; Aujesky, Drahomir; Collet, Tinh-Hai; Ford, Ian; Gussekloo, Jacobijn; Kearney, Patricia M; McCarthy, Vera J C; Mooijaart, Simon; Poortvliet, Rosalinde K E; Quinn, Terence; Stott, David J; Watt, Torquil; Westendorp, Rudi; Rodondi, Nicolas; Bauer, Douglas C (2020). L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial. Annals of internal medicine, 172(11), pp. 709-716. American College of Physicians 10.7326/M19-3193
Gonzalez Rodriguez, Elena; Stuber, Mirah; Del Giovane, Cinzia; Feller, Martin; Collet, Tinh-Hai; Löwe, Axel L; Blum, Manuel R; van Vliet, Nicolien A; van Heemst, Diana; Kearney, Patricia M; Gussekloo, Jacobijn; Mooijaart, Simon; Westendorp, Rudi G J; Stott, David J; Aeberli, Daniel; Bauer, Douglas C; Hans, Didier; Rodondi, Nicolas (2020). Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. Journal of clinical endocrinology and metabolism, 105(1), dgz058. Endocrine Society 10.1210/clinem/dgz058
Mooijaart, Simon P; Du Puy, Robert S; Stott, David J; Kearney, Patricia M; Rodondi, Nicolas; Westendorp, Rudi G J; den Elzen, Wendy P J; Postmus, Iris; Poortvliet, Rosalinde K E; van Heemst, Diana; van Munster, Barbara C; Peeters, Robin P; Ford, Ian; Kean, Sharon; Messow, Claudia-Martina; Blum, Manuel R; Collet, Tinh-Hai; Watt, Torquil; Dekkers, Olaf M; Jukema, J Wouter; ... (2019). Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism. JAMA - the journal of the American Medical Association, 322(20), pp. 1977-86. American Medical Association 10.1001/jama.2019.17274
Meuwese, Christiaan L; van Diepen, Merel; Cappola, Anne R; Sarnak, Mark J; Shlipak, Michael G; Bauer, Douglas C; Fried, Linda P; Iacoviello, Massimo; Vaes, Bert; Degryse, Jean; Khaw, Kay-Tee; Luben, Robert N; Åsvold, Bjørn O; Bjøro, Trine; Vatten, Lars J; de Craen, Anton J M; Trompet, Stella; Iervasi, Giorgio; Molinaro, Sabrina; Ceresini, Graziano; ... (2019). Low thyroid function is not associated with an accelerated deterioration in renal function. Nephrology, dialysis, transplantation, 34(4), pp. 650-659. Oxford University Press 10.1093/ndt/gfy071
Sabater-Lleal, Maria; Huffman, Jennifer E; de Vries, Paul S; Marten, Jonathan; Mastrangelo, Michael A; Song, Ci; Pankratz, Nathan; Ward-Caviness, Cavin K; Yanek, Lisa R; Trompet, Stella; Delgado, Graciela E; Guo, Xiuqing; Bartz, Traci M; Martinez-Perez, Angel; Germain, Marine; de Haan, Hugoline G; Ozel, Ayse B; Polasek, Ozren; Smith, Albert V; Eicher, John D; ... (2019). Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels. Circulation, 139(5), pp. 620-635. Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.118.034532
Ligthart, Symen; Vaez, Ahmad; Võsa, Urmo; Stathopoulou, Maria G; de Vries, Paul S; Prins, Bram P; Van der Most, Peter J; Tanaka, Toshiko; Naderi, Elnaz; Rose, Lynda M; Wu, Ying; Karlsson, Robert; Barbalic, Maja; Lin, Honghuang; Pool, René; Zhu, Gu; Macé, Aurélien; Sidore, Carlo; Trompet, Stella; Mangino, Massimo; ... (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American journal of human genetics, 103(5), pp. 691-706. Cell Press 10.1016/j.ajhg.2018.09.009
Wopereis, Daisy M; Du Puy, Robert S; van Heemst, Diana; Walsh, John P; Bremner, Alexandra; Bakker, Stephan J L; Bauer, Douglas C; Cappola, Anne R; Ceresini, Graziano; Degryse, Jean; Dullaart, Robin P F; Feller, Martin; Ferrucci, Luigi; Floriani, Carmen; Franco, Oscar H; Iacoviello, Massimo; Iervasi, Georgio; Imaizumi, Misa; Jukema, J Wouter; Khaw, Kay-Tee; ... (2018). The relation between thyroid function and anemia: a pooled analysis of individual participant data. Journal of clinical endocrinology and metabolism, 103(10), pp. 3658-3667. Endocrine Society 10.1210/jc.2018-00481
Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael; ... (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature genetics, 50(10), pp. 1412-1425. Nature America 10.1038/s41588-018-0205-x
Blum, Manuel R; Gencer, Baris; Adam, Luise; Feller, Martin; Collet, Tinh-Hai; Da Costa, Bruno R; Moutzouri, Elisavet; Dopheide, Jörn; Depairon, Michèle; Sykiotis, Gerasimos P; Kearney, Patricia; Gussekloo, Jacobijn; Westendorp, Rudi; Stott, David J; Bauer, Douglas C; Rodondi, Nicolas (2018). Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly with Subclinical Hypothyroidism: A Randomized Trial. The Journal of clinical endocrinology and metabolism, 103(8), pp. 2988-2997. The Endocrine Society 10.1210/jc.2018-00279
Baumgartner, Christine; Da Costa, Bruno R; Collet, Tinh-Hai; Feller, Martin; Floriani, Carmen; Bauer, Douglas C; Cappola, Anne R; Heckbert, Susan R; Ceresini, Graziano; Gussekloo, Jacobijn; den Elzen, Wendy P J; Peeters, Robin P; Luben, Robert; Völzke, Henry; Dörr, Marcus; Walsh, John P; Bremner, Alexandra; Iacoviello, Massimo; Macfarlane, Peter; Heeringa, Jan; ... (2017). Thyroid Function Within the Normal Range, Subclinical Hypothyroidism and the Risk of Atrial Fibrillation. Circulation, 136(22), pp. 2100-2116. Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.117.028753
Stott, David J; Rodondi, Nicolas; Bauer, Douglas C (2017). Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism- Correspondence. New England journal of medicine NEJM, 377(14), e20. Massachusetts Medical Society MMS 10.1056/NEJMc1709989
Aubert, Carole E; Floriani, Carmen; Bauer, Douglas C; Da Costa, Bruno; Segna, Daniel; Blum, Manuel R; Collet, Tinh-Hai; Fink, Howard A; Cappola, Anne R; Syrogiannouli, Lamprini; Peeters, Robin P; Åsvold, Bjørn O; den Elzen, Wendy Pj; Luben, Robert N; Bremner, Alexandra P; Gogakos, Apostolos; Eastell, Richard; Kearney, Patricia M; Hoff, Mari; Le Blanc, Erin; ... (2017). Thyroid function tests in the reference range and fracture: individual participant analysis of prospective cohorts. Journal of clinical endocrinology and metabolism, 102(8), pp. 2719-2728. Endocrine Society 10.1210/jc.2017-00294
Stott, David J; Rodondi, Nicolas; Kearney, Patricia M; Ford, Ian; Westendorp, Rudi G J; Mooijaart, Simon P; Sattar, Naveed; Aubert, Carole E; Aujesky, Drahomir; Bauer, Douglas C; Baumgartner, Christine; Blum, Manuel R; Browne, John P; Byrne, Stephen; Collet, Tinh-Hai; Dekkers, Olaf M; den Elzen, Wendy P J; Du Puy, Robert S; Ellis, Graham; Feller, Martin; ... (2017). Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. New England journal of medicine NEJM, 376(26), pp. 2534-2544. Massachusetts Medical Society MMS 10.1056/NEJMoa1603825
Stott, David J; Gussekloo, Jacobijn; Kearney, Patricia M; Rodondi, Nicolas; Westendorp, Rudi G J; Mooijaart, Simon; Kean, Sharon; Quinn, Terence J; Sattar, Naveed; Hendry, Kirsty; Du Puy, Robert; Den Elzen, Wendy P J; Poortvliet, Rosalinde K E; Smit, Jan W A; Jukema, J Wouter; Dekkers, Olaf M; Blum, Manuel; Collet, Tinh-Hai; McCarthy, Vera; Hurley, Caroline; ... (2017). Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST). BMC Endocrine Disorders, 17(1), p. 6. BioMed Central 10.1186/s12902-017-0156-8
Adams, Hieab H H; Hibar, Derrek P; Chouraki, Vincent; Stein, Jason L; Nyquist, Paul A; Rentería, Miguel E; Trompet, Stella; Arias-Vasquez, Alejandro; Seshadri, Sudha; Desrivières, Sylvane; Beecham, Ashley H; Jahanshad, Neda; Wittfeld, Katharina; Van der Lee, Sven J; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S; ... (2016). Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature neuroscience, 19(12), pp. 1569-1582. Nature America 10.1038/nn.4398
Chaker, Layal; Baumgartner, Christine; den Elzen, Wendy P J; Collet, Tinh-Hai; Ikram, M Arfan; Blum, Manuel; Dehghan, Abbas; Drechsler, Christiane; Luben, Robert N; Portegies, Marileen L P; Iervasi, Giorgio; Medici, Marco; Stott, David J; Dullaart, Robin P; Ford, Ian; Bremner, Alexandra; Newman, Anne B; Wanner, Christoph; Sgarbi, José A; Dörr, Marcus; ... (2016). Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis. The Journal of clinical endocrinology and metabolism, 101(11), pp. 4270-4282. The Endocrine Society 10.1210/jc.2016-2255
Blum, Manuel; Wijsman, Liselotte W; Virgini, Vanessa S; Bauer, Douglas C; den Elzen, Wendy P J; Jukema, J Wouter; Buckley, Brendan M; de Craen, Anton J M; Kearney, Patricia M; Stott, David J; Gussekloo, Jacobjin; Westendorp, Rudi G J; Mooijaart, Simon P; Rodondi, Nicolas (2016). Subclinical Thyroid Dysfunction and Depressive Symptoms among Elderly: A Prospective Cohort Study. Neuroendocrinology, 103(3-4), pp. 291-299. Karger 10.1159/000437387
Åsvold, Bjørn O; Vatten, Lars J; Bjøro, Trine; Bauer, Douglas C; Bremner, Alexandra; Cappola, Anne R; Ceresini, Graziano; den Elzen, Wendy P J; Ferrucci, Luigi; Franco, Oscar H; Franklyn, Jayne A; Gussekloo, Jacobijn; Iervasi, Giorgio; Imaizumi, Misa; Kearney, Patricia M; Khaw, Kay-Tee; Maciel, Rui M B; Newman, Anne B; Peeters, Robin P; Psaty, Bruce M; ... (2015). Thyroid function within the normal range and risk of coronary heart disease: an individual participant data analysis of 14 cohorts. JAMA Internal Medicine, 175(6), pp. 1037-1047. American Medical Association 10.1001/jamainternmed.2015.0930
Chaker, Layal; Baumgartner, Christine; den Elzen, Wendy P J; Ikram, M Arfan; Blum, Manuel; Collet, Tinh-Hai; Bakker, Stephan J L; Dehghan, Abbas; Drechsler, Christiane; Luben, Robert N; Hofman, Albert; Portegies, Marileen L P; Medici, Marco; Iervasi, Giorgio; Stott, David J; Ford, Ian; Bremner, Alexandra; Wanner, Christoph; Ferrucci, Luigi; Newman, Anne B; ... (2015). Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. Journal of clinical endocrinology and metabolism, 100(6), pp. 2181-2191. Endocrine Society 10.1210/jc.2015-1438
Blum, Manuel R; Bauer, Douglas C; Collet, Tinh-Hai; Fink, Howard A; Cappola, Anne R; da Costa, Bruno R; Wirth, Christina D; Peeters, Robin P; Åsvold, Bjørn O; den Elzen, Wendy P J; Luben, Robert N; Imaizumi, Misa; Bremner, Alexandra P; Gogakos, Apostolos; Eastell, Richard; Kearney, Patricia M; Strotmeyer, Elsa S; Wallace, Erin R; Hoff, Mari; Ceresini, Graziano; ... (2015). Subclinical thyroid dysfunction and fracture risk: a meta-analysis. JAMA - the journal of the American Medical Association, 313(20), pp. 2055-2065. American Medical Association 10.1001/jama.2015.5161
Stott, David J; Bauer, Douglas C; Ford, Ian; Kearney, Patricia; Gussekloo, Jacobijn; Quinn, Terence J; Rodondi, Nicolas; Smit, Jan; Westerdorp, Rudi (2014). The Dilemma of Treating Subclinical Hypothyroidism: Risk that Current Guidelines Do More Harm than Good. European thyroid journal, 3(2), pp. 137-138. Karger 10.1159/000360621
Lubitz, Steven A; Lunetta, Kathryn L; Lin, Honghuang; Arking, Dan E; Trompet, Stella; Li, Guo; Krijthe, Bouwe P; Chasman, Daniel I; Barnard, John; Kleber, Marcus E; Dörr, Marcus; Ozaki, Kouichi; Smith, Albert V; Müller-Nurasyid, Martina; Walter, Stefan; Agarwal, Sunil K; Bis, Joshua C; Brody, Jennifer A; Chen, Lin Y; Everett, Brendan M; ... (2014). Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. Journal of the American College of Cardiology, 63(12), pp. 1200-1210. Elsevier 10.1016/j.jacc.2013.12.015
Virgini, Vanessa Sophie; Wijsman, Liselotte W; Rodondi, Nicolas; Bauer, Douglas C; Kearney, Patricia M; Gussekloo, Jacobijn; den Elzen, Wendy P J; Jukema, J Wouter; Westendorp, Rudi G J; Ford, Ian; Stott, David J; Mooijaart, Simon P (2014). Subclinical thyroid dysfunction and functional capacity among elderly. Thyroid, 24(2), pp. 208-214. Mary Ann Liebert 10.1089/thy.2013.0071
Nanchen, David; Stott, David J; Gussekloo, Jacobijn; Mooijaart, Simon P; Westendorp, Rudi G J; Jukema, J Wouter; Macfarlane, Peter W; Cornuz, Jacques; Rodondi, Nicolas; Buckley, Brendan M; Ford, Ian; Sattar, Naveed; de Craen, Anton J M; PROSPER Group, (2013). Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study. European journal of heart failure, 15(5), pp. 581-8. Oxford: Oxford University Press 10.1093/eurjhf/hfs195
Wijsman, Liselotte W; de Craen, Anton J M; Trompet, Stella; Gussekloo, Jacobijn; Stott, David J; Rodondi, Nicolas; Welsh, Paul; Jukema, J Wouter; Westendorp, Rudi G J; Mooijaart, Simon P (2013). Subclinical thyroid dysfunction and cognitive decline in old age. PLoS ONE, 8(3), e59199. Public Library of Science 10.1371/journal.pone.0059199
Quinn, Terence J; Gussekloo, Jacobijn; Kearney, Patricia; Rodondi, Nicolas; Stott, David J (2012). Subclinical thyroid disorders. Lancet, 380(9839), 335-6; author reply 336-7. London: Elsevier 10.1016/S0140-6736(12)61242-2
Nanchen, David; Gussekloo, Jacobijn; Westendorp, Rudi G J; Stott, David J; Jukema, J Wouter; Trompet, Stella; Ford, Ian; Welsh, Paul; Sattar, Naveed; Macfarlane, Peter W; Mooijaart, Simon P; Rodondi, Nicolas; de Craen, Anton J M; PROSPER, Group (2012). Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk. Journal of clinical endocrinology and metabolism, 97(3), pp. 852-61. Chevy Chase, Md.: Endocrine Society 10.1210/jc.2011-1978
