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Lucas, Cécily; Sauter, Kay-Sara; Steigert, Michael; Mallet, Delphine; Wilmouth, James; Olabe, Julie; Plotton, Ingrid; Morel, Yves; Aeberli, Daniel; Wagner, Franca; Clevers, Hans; Pandey, Amit V; Val, Pierre; Roucher-Boulez, Florence; Fluck, Christa E (2023). Loss of LGR4/GPR48 causes severe neonatal salt-wasting due to disrupted WNT signaling altering adrenal zonation. The journal of clinical investigation, 133(4) American Society for Clinical Investigation 10.1172/JCI164915
Strumann, Christoph; Ranzani, Otavio T; Moor, Jeanne; Berner, Reinhard; Toepfner, Nicole; Chao, Cho-Ming; Moor, Matthias B (2023). Effectiveness of BNT162b2 mRNA Covid-19 vaccine in children under 5 years. Journal of clinical investigation, 133(21), e173329. American Society for Clinical Investigation 10.1172/JCI173329
Johann, Lisa; Soldati, Sasha; Müller, Kristin; Lampe, Josephine; Marini, Federico; Klein, Matthias; Schramm, Eva; Ries, Nathalie; Schelmbauer, Carsten; Palagi, Ilaria; Karram, Khalad; Assmann, Julian C; Khan, Mahtab A; Wenzel, Jan; Schmidt, Mirko Hh; Körbelin, Jakob; Schlüter, Dirk; van Loo, Geert; Bopp, Tobias; Engelhardt, Britta; ... (2023). A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS. The journal of clinical investigation, 133(24) American Society for Clinical Investigation 10.1172/JCI168314
Gehin, Charlotte; Lone, Museer A; Lee, Winston; Capolupo, Laura; Ho, Sylvia; Adeyemi, Adekemi M; Gerkes, Erica H; Stegmann, Alexander Pa; López-Martín, Estrella; Bermejo-Sánchez, Eva; Martínez-Delgado, Beatriz; Zweier, Christiane; Kraus, Cornelia; Popp, Bernt; Strehlow, Vincent; Gräfe, Daniel; Knerr, Ina; Jones, Eppie R; Zamuner, Stefano; Abriata, Luciano A; ... (2023). CERT1 mutations perturb human development by disrupting sphingolipid homeostasis. The journal of clinical investigation, 133(10) American Society for Clinical Investigation 10.1172/JCI165019
Guo, Yuchen; Gabola, Monica; Lattanzio, Rossano; Paul, Conception; Pinet, Valérie; Tang, Ruizhi; Turali, Hulya; Bremond, Julie; Longobardi, Ciro; Maurizy, Chloé; Da Costa, Quentin; Finetti, Pascal; Boissière-Michot, Florence; Rivière, Benjamin; Lemmers, Céline; Garnier, Séverine; Bertucci, François; Zlobec, Inti; Chebli, Karim; Tazi, Jamal; ... (2021). Cyclin A2 maintains colon homeostasis and is a prognostic factor in CRC. The journal of clinical investigation, 131(4) American Society for Clinical Investigation 10.1172/JCI131517
Li, Zhilin; Korhonen, Emilia A; Merlini, Arianna; Strauss, Judith; Wihuri, Eleonoora; Nurmi, Harri; Antila, Salli; Paech, Jennifer; Deutsch, Urban; Engelhardt, Britta; Chintharlapalli, Sudhakar; Koh, Gou Young; Flügel, Alexander; Alitalo, Kari (2020). Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS. The journal of clinical investigation, 130(4), pp. 1977-1990. American Society for Clinical Investigation 10.1172/JCI130308
Stivala, Simona; Codilupi, Tamara; Brkic, Sime; Baerenwaldt, Anne; Ghosh, Nilabh; Hao-Shen, Hui; Dirnhofer, Stephan; Dettmer, Matthias S.; Simillion, Cedric; Kaufmann, Beat A; Chiu, Sophia; Keller, Matthew; Kleppe, Maria; Hilpert, Morgane; Buser, Andreas S; Passweg, Jakob R; Radimerski, Thomas; Skoda, Radek C; Levine, Ross L and Meyer, Sara C (2019). Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms. The journal of clinical investigation, 129(4), pp. 1596-1611. American Society for Clinical Investigation 10.1172/JCI98785
Shoag, Jonathan; Liu, Deli; Blattner, Mirjam; Sboner, Andrea; Park, Kyung; Deonarine, Lesa; Robinson, Brian D; Mosquera, Juan Miguel; Chen, Yu; Rubin, Mark Andrew; Barbieri, Christopher E (2018). SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG. Journal of clinical investigation, 128(1), pp. 381-386. American Society for Clinical Investigation 10.1172/JCI96551
McNair, Christopher; Xu, Kexin; Mandigo, Amy C; Benelli, Matteo; Leiby, Benjamin; Rodrigues, Daniel; Lindberg, Johan; Gronberg, Henrik; Crespo, Mateus; De Laere, Bram; Dirix, Luc; Visakorpi, Tapio; Li, Fugen; Feng, Felix Y; de Bono, Johann; Demichelis, Francesca; Rubin, Mark Andrew; Brown, Myles; Knudsen, Karen E (2018). Differential impact of RB status on E2F1 reprogramming in human cancer. Journal of clinical investigation, 128(1), pp. 341-358. American Society for Clinical Investigation 10.1172/JCI93566
Yu, Kang; Davidson, Chelsea L; Wójtowicz, Agnieszka; Lisboa, Luiz; Wang, Ting; Airo, Adriana M; Villard, Jean; Buratto, Jeremie; Sandalova, Tatyana; Achour, Adnane; Humar, Atul; Boggian, Katia; Cusini, Alexia; van Delden, Christian; Egli, Adrian; Manuel, Oriol; Mueller, Nicolas; Bochud, Pierre-Yves; Burshtyn, Deborah N (2018). LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions. Journal of clinical investigation, 128(4), pp. 1523-1537. American Society for Clinical Investigation 10.1172/JCI96174
Chennupati, Vijaykumar; Veiga, Diogo Ft; Maslowski, Kendle M; Andina, Nicola; Tardivel, Aubry Bernard Maurice; Yu, Eric Chi-Wang; Stilinovic, Martina; Simillion, Cedric; Duchosal, Michel A; Quadroni, Manfredo; Roberts, Irene; Sankaran, Vijay G; MacDonald, H Robson; Fasel, Nicolas; Angelillo, Anne; Schneider, Pascal; Hoang, Trang; Allam, Ramanjaneyulu (2018). Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation. Journal of clinical investigation, 128(4), pp. 1597-1614. American Society for Clinical Investigation 10.1172/JCI94956
Stanczak, Michal A; Siddiqui, Shoib S; Trefny, Marcel P; Thommen, Daniela S; Frias Boligan, Kayluz; von Gunten, Stephan; Tzankov, Alexandar; Tietze, Lothar; Lardinois, Didier; Heinzelmann-Schwarz, Viola; von Bergwelt-Baildon, Michael S; Zhang, Wu; Lenz, Heinz-Josef; Han, Younghan; Amos, Christopher I; Syedbasha, Mohammedyaseen; Egli, Adrian; Stenner, Frank; Speiser, Daniel E; Varki, Ajit; ... (2018). Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells. Journal of clinical investigation, 128(11), pp. 4912-4923. American Society for Clinical Investigation 10.1172/JCI120612
Naschberger, E.; Liebl, A.; Schellerer, V. S.; Schutz, M.; Britzen-Laurent, N.; Kolbel, P.; Schaal, U.; Haep, L.; Regensburger, D.; Wittmann, T.; Klein-Hitpass, L.; Rau, Tilman; Dietel, B.; Meniel, V. S.; Clarke, A. R.; Merkel, S.; Croner, R. S.; Hohenberger, W.; Sturzl, M. (2016). Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma. Journal of clinical investigation, 126(11), pp. 4187-4204. American Society for Clinical Investigation 10.1172/JCI78260
Dallavalle, Cecilia; Albino, Domenico; Civenni, Gianluca; Merulla, Jessica; Ostano, Paola; Mello-Grand, Maurizia; Rossi, Simona; Losa, Marco; D'Ambrosio, Gioacchino; Sessa, Fausto; Thalmann, George; Garcia-Escudero, Ramon; Zitella, Andrea; Chiorino, Giovanna; Catapano, Carlo V; Carbone, Giuseppina M (2016). MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression. Journal of clinical investigation, 126(12), pp. 4585-4602. American Society for Clinical Investigation 10.1172/JCI86505
Drost, Rinske; Dhillon, Kiranjit K; van der Gulden, Hanneke; van der Heijden, Ingrid; Brandsma, Inger; Cruz, Cristina; Chondronasiou, Dafni; Castroviejo-Bermejo, Marta; Boon, Ute; Schut, Eva; van der Burg, Eline; Wientjens, Ellen; Pieterse, Mark; Klijn, Christiaan; Klarenbeek, Sjoerd; Loayza-Puch, Fabricio; Elkon, Ran; van Deemter, Liesbeth; Rottenberg, Sven; van de Ven, Marieke; ... (2016). BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. Journal of clinical investigation, 126(8), pp. 2903-2918. American Society for Clinical Investigation 10.1172/JCI70196
Huth, Markus; Han, Kyu-Hee; Sotoudeh, Kayvon; Hsieh, Yi-Ju; Effertz, Thomas; Vu, Andrew A; Verhoeven, Sarah; Hsieh, Michael H; Greenhouse, Robert; Cheng, Alan G; Ricci, Anthony J (2015). Designer aminoglycosides prevent cochlear hair cell loss and hearing loss. Journal of clinical investigation, 125(2), pp. 583-592. American Society for Clinical Investigation 10.1172/JCI77424
Mager, Lukas; Riether, Carsten; Schürch, Christian; Banz Wälti, Yara; Wasmer, Marie-Hélène Christin; Stuber Roos, Regula; Theocharides, Alexandre; Li, Xiaohong; Xia, Yu; Saito, Hirohisa; Nakae, Susumu; Baerlocher, Gabriela M.; Manz, Markus G; McCoy, Kathleen; Macpherson, Andrew; Ochsenbein, Adrian; Beutler, Bruce; Krebs, Philippe (2015). IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. Journal of clinical investigation, 125(7), pp. 2579-2591. American Society for Clinical Investigation 10.1172/JCI77347
Sabine, Amélie; Bovay, Esther; Demir, Cansaran Saygili; Kimura, Wataru; Jaquet, Muriel; Agalarov, Yan; Zangger, Nadine; Scallan, Joshua P; Graber, Werner Adrian; Gulpinar, Elgin; Kwak, Brenda R; Mäkinen, Taija; Martinez-Corral, Inés; Ortega, Sagrario; Delorenzi, Mauro; Kiefer, Friedemann; Davis, Michael J; Djonov, Valentin; Miura, Naoyuki and Petrova, Tatiana V (2015). FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature. Journal of clinical investigation, 125(10), pp. 3861-3877. American Society for Clinical Investigation 10.1172/JCI80454
Jandus, Camilla; Frias Boligan, Kayluz; Chijioke, Obinna; Liu, He; Dahlhaus, Meike; Demoulins, Thomas; Schneider, Christoph; Wehrli, Marc; Hunger, Robert E.; Baerlocher, Gabriela M.; Simon, Hans-Uwe; Romero, Pedro; Münz, Christian; von Gunten, Stephan (2014). Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance. Journal of clinical investigation, 124(4), pp. 1810-1820. American Society for Clinical Investigation 10.1172/JCI65899
Sanchez Rodriguez, Robert; Pauli, Mariela L; Neuhaus, Isaac M; Yu, Siegrid S; Arron, Sarah T; Harris, Hobart W; Yang, Sara Hsin-Yi; Anthony, Bryan A; Sverdrup, Francis M; Krow-Lucal, Elisabeth; MacKenzie, Tippi C; Johnson, David S; Meyer, Everett H; Löhr, Andrea; Hsu, Andro; Koo, John; Liao, Wilson; Gupta, Rishu; Debbaneh, Maya G; Butler, Daniel; ... (2014). Memory regulatory T cells reside in human skin. Journal of clinical investigation, 124(3), pp. 1027-1036. American Society for Clinical Investigation 10.1172/JCI72932
Tokonami, Natsuko; Morla, Luciana; Centeno, Gabriel; Mordasini, David; Ramakrishnan, Suresh Krishna; Nikolaeva, Svetlana; Wagner, Carsten A; Bonny, Olivier; Houillier, Pascal; Doucet, Alain; Firsov, Dmitri (2013). α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism. Journal of clinical investigation, 123(7), pp. 3166-71. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI67562
Rexhaj, Emrush; Paoloni-Giacobino, Ariane; Rimoldi, Stefano F.; Fuster, Daniel Guido; Anderegg, Manuel; Somm, Emmanuel; Bouillet, Elisa; Allemann, Yves; Sartori, Claudio; Scherrer, Urs (2013). Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span. Journal of clinical investigation, 123(12), pp. 5052-5060. American Society for Clinical Investigation 10.1172/JCI68943
Papacleovoulou, Georgia; Abu-Hayyeh, Shadi; Nikolopoulou, Evanthia; Briz, Oscar; Owen, Bryn M.; Nikolova, Vanya; Ovadia, Caroline; Huang, Xiao; Vaarasmaki, Marja; Baumann, Marc; Jansen, Eugene; Albrecht, Christiane; Jarvelin, Marjo-Riitta; Marin, Jose J. G.; Knisely, A. S.; Williamson, Catherine (2013). Maternal cholestasis during pregnancy programs metabolic disease in offspring. Journal of clinical investigation, 123(7), pp. 3172-3181. American Society for Clinical Investigation 10.1172/JCI68927
Laedermann, Cédric; Cachemaille, Matthieu; Kirschmann, Guylène; Pertin, Marie; Gosselin, Romain-Daniel; Chang, Isabelle; Albesa, Maxime; Towne, Chris; Schneider, Bernard L.; Kellenberger, Stephan; Abriel, Hugues; Decosterd, Isabelle (2013). Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain. Journal of clinical investigation, 123(7), pp. 3002-3013. American Society for Clinical Investigation 10.1172/JCI68996
Ziegler, Tilman; Horstkotte, Jan; Schwab, Claudia; Pfetsch, Vanessa; Weinmann, Karolina; Dietzel, Steffen; Rohwedder, Ina; Hinkel, Rabea; Gross, Lisa; Lee, Seungmin; Hu, Junhao; Soehnlein, Oliver; Franz, Wolfgang M.; Sperandio, Markus; Pohl, Ulrich; Thomas, Markus; Weber, Christian; Augustin, Hellmut G.; Fässler, Reinhard; Deutsch, Urban; ... (2013). Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. Journal of clinical investigation, 123(8), pp. 3436-3445. American Society for Clinical Investigation 10.1172/JCI66549
Schürch, Christian; Riether, Carsten; Matter, Matthias S; Tzankov, Alexandar; Ochsenbein, Adrian (2012). CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression. Journal of clinical investigation, 122(2), pp. 624-38. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI45977
McCarthy, Douglas D; Kujawa, Julie; Wilson, Cheryl; Papandile, Adrian; Poreci, Urjana; Porfilio, Elisa A; Ward, Lesley; Lawson, Melissa A E; Macpherson, Andrew J; McCoy, Kathy D; Pei, York; Novak, Lea; Lee, Jeannette Y; Julian, Bruce A; Novak, Jan; Ranger, Ann; Gommerman, Jennifer L; Browning, Jeffrey L (2011). Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy. Journal of clinical investigation, 121(10), pp. 3991-4002. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI45563
Rotger, Margalida; Dalmau, Judith; Rauch, Andri; McLaren, Paul; Bosinger, Steven E; Martinez, Raquel; Sandler, Netanya G; Roque, Annelys; Liebner, Julia; Battegay, Manuel; Bernasconi, Enos; Descombes, Patrick; Erkizia, Itziar; Fellay, Jacques; Hirschel, Bernard; Miró, Jose M; Palou, Eduard; Hoffmann, Matthias; Massanella, Marta; Blanco, Julià; ... (2011). Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. Journal of clinical investigation, 121(6), pp. 2391-400. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI45235
Derré, Laurent; Rivals, Jean-Paul; Jandus, Camilla; Pastor, Sonia; Rimoldi, Donata; Romero, Pedro; Michielin, Olivier; Olive, Daniel; Speiser, Daniel E (2010). BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. Journal of clinical investigation, 120(1), pp. 157-67. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI40070
Mudter, Jonas; Amoussina, Lioubov; Schenk, Mirjam; Yu, Jingling; Brüstle, Anne; Weigmann, Benno; Atreya, Raja; Wirtz, Stefan; Becker, Christoph; Hoffman, Arthur; Atreya, Imke; Biesterfeld, Stefan; Galle, Peter R; Lehr, Hans A; Rose-John, Stefan; Mueller, Christoph; Lohoff, Michael; Neurath, Markus F (2008). The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. Journal of clinical investigation, 118(7), pp. 2415-26. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI33227
Yang, Zhenglin; Chen, Yali; Lillo, Concepcion; Chien, Jeremy; Yu, Zhengya; Michaelides, Michel; Klein, Martin; Howes, Kim A; Li, Yang; Kaminoh, Yuuki; Chen, Haoyu; Zhao, Chao; Chen, Yuhong; Al-Sheikh, Youssef Tawfik; Karan, Goutam; Corbeil, Denis; Escher, Pascal; Kamaya, Shin; Li, Chunmei; Johnson, Samantha; ... (2008). Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. Journal of clinical investigation, 118(8), pp. 2908-2916. American Society for Clinical Investigation 10.1172/JCI35891
Schenk, Mirjam; Bouchon, Axel; Seibold, Frank; Mueller, Christoph (2007). TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. Journal of clinical investigation, 117(10), pp. 3097-3106. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI30602
Corazza, Nadia; Jakob, Sabine; Schaer, Corinne; Frese, Steffen; Keogh, Adrian; Stroka, Deborah; Kassahn, Daniela; Torgler, Ralph; Mueller, Christoph; Schneider, Pascal; Brunner, Thomas (2006). TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. Journal of clinical investigation, 116(9), pp. 2493-9. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI27726
Patsouris, David; Mandard, Stéphane; Voshol, Peter J; Escher, Pascal; Tan, Nguan Soon; Havekes, Louis M; Koenig, Wolfgang; März, Winfried; Tafuri, Sherrie; Wahli, Walter; Müller, Michael; Kersten, Sander (2004). PPARalpha governs glycerol metabolism. Journal of clinical investigation, 114(1), pp. 94-103. American Society for Clinical Investigation 10.1172/JCI20468
Wasem, Christoph; Arnold, Diana; Saurer, Leslie; Corazza, Nadia; Jakob, Sabine; Herren, Simon; Vallan, Claudio; Mueller, Christoph; Brunner, Thomas (2003). Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence. Journal of clinical investigation, 111(8), pp. 1191-1199. American Society for Clinical Investigation 10.1172/JCI16344
Hunger, R E; Carnaud, C; Vogt, I; Mueller, C (1998). Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice. Journal of clinical investigation, 101(6), pp. 1300-1309. American Society for Clinical Investigation 10.1172/JCI1230
Leib, Stephen; Kim, Y S; Chow, L L; Sheldon, R A; Täuber, Martin G. (1996). Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. Journal of clinical investigation, 98(11), pp. 2632-2639. American Society for Clinical Investigation 10.1172/JCI119084
Hunger, R E; Müller, S; Laissue, J A; Hess, M W; Carnaud, C; Garcia, I; Mueller, C (1996). Inhibition of submandibular and lacrimal gland infiltration in nonobese diabetic mice by transgenic expression of soluble TNF-receptor p55. Journal of clinical investigation, 98(4), pp. 954-961. American Society for Clinical Investigation 10.1172/JCI118879
Christen, S; Thomas, SR; Garner, B; Stocker, R (1994). Inhibition by interferon-gamma of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway. Journal of clinical investigation, 93(5), pp. 2149-58. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI117211
Tureen, JH; Täuber, MG; Sande, MA (1992). Effect of hydration status on cerebral blood flow and cerebrospinal fluid lactic acidosis in rabbits with experimental meningitis. Journal of clinical investigation, 89(3), pp. 947-53. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI115676
Diem, P; Redmon, JB; Abid, M; Moran, A; Sutherland, D.E.; Halter, JB; Robertson, RP (1990). Glucagon, catecholamine and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts. Journal of clinical investigation, 86(6), pp. 2008-13. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI114936
