Granulocyte death mediated by specific antibodies in intravenous immunoglobulin (IVIG).

Graeter, Stefanie; Simon, Hans-Uwe; von Gunten, Stephan (2020). Granulocyte death mediated by specific antibodies in intravenous immunoglobulin (IVIG). Pharmacological research, 154, p. 104168. Elsevier 10.1016/j.phrs.2019.02.007

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Granulocytes are key effector cells of the innate immune system that cause substantial by-stander tissue damage in a broad range of inflammatory disorders. Specific antibodies with the potential to regulate granulocyte survival are present in polyclonal intravenous immunoglobulin (IVIG) preparations and may contribute to the anti-inflammatory effects of high-dose IVIG therapy. Here, we discuss idiosyncratic characteristics of antibodies to FAS and Siglecs contained in IVIG pertaining to granulocyte death regulation and highlight implications for research and clinical practice.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Graeter, Stefanie; Simon, Hans-Uwe and von Gunten, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1043-6618

Publisher:

Elsevier

Language:

English

Submitter:

Celine Joray

Date Deposited:

23 Apr 2019 13:21

Last Modified:

01 Dec 2020 15:51

Publisher DOI:

10.1016/j.phrs.2019.02.007

PubMed ID:

30738127

Uncontrolled Keywords:

Eosinophils FAS Granulocytes High-dose IVIG IVIG Immunomodulation Intravenous immunoglobulin Neutrophils Siglec-8 Siglec-9

BORIS DOI:

10.7892/boris.127438

URI:

https://boris.unibe.ch/id/eprint/127438

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