The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence

Contu, Lara; Steiner, Silvio; Thiel, Volker Earl; Mühlemann, Oliver (2019). The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence. CHIMIA, 73(6), pp. 374-379. Schweizerische Chemische Gesellschaft 10.2533/chimia.2019.374

[img] Text
Contu_Chimia2019_NCCR review.pdf - Published Version
Restricted to registered users only until 1 July 2020.
Available under License Publisher holds Copyright.

Download (195kB) | Request a copy

Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic processes that are vital for maintenance of cellular homeostasis - 1) the nonsense-mediated mRNA decay (NMD) pathway and 2) the transient formation of stress granules (SG) - and explore the current literature on their roles in antiviral defence. Within the NCCR RNA & Disease, the laboratories of Proffs. O. Mühlemann and Volker Thiel teamed up to unravel the roles of NMD and SGs, and their interconnections in defending cells from alphavirus and coronavirus infections.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
08 Faculty of Science > Departement of Chemistry and Biochemistry
08 Faculty of Science > Departement of Chemistry and Biochemistry > NCCR RNA & Disease

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Contu, Lara; Steiner, Silvio; Thiel, Volker Earl and Mühlemann, Oliver

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0009-4293

Publisher:

Schweizerische Chemische Gesellschaft

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

06 Jun 2019 09:37

Last Modified:

06 Jun 2019 09:37

Publisher DOI:

10.2533/chimia.2019.374

BORIS DOI:

10.7892/boris.131147

URI:

https://boris.unibe.ch/id/eprint/131147

Actions (login required)

Edit item Edit item
Provide Feedback