The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence

Contu, Lara; Steiner, Silvio; Thiel, Volker; Mühlemann, Oliver (2019). The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence. CHIMIA, 73(6), pp. 374-379. Schweizerische Chemische Gesellschaft 10.2533/chimia.2019.374

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Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic processes that are vital for maintenance of cellular homeostasis - 1) the nonsense-mediated mRNA decay (NMD) pathway and 2) the transient formation of stress granules (SG) - and explore the current literature on their roles in antiviral defence. Within the NCCR RNA & Disease, the laboratories of Proffs. O. Mühlemann and Volker Thiel teamed up to unravel the roles of NMD and SGs, and their interconnections in defending cells from alphavirus and coronavirus infections.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) 08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) 08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) > NCCR RNA & Disease
Graduate School:	Graduate School for Cellular and Biomedical Sciences (GCB)
UniBE Contributor:	Contu, Lara, Steiner, Silvio, Thiel, Volker Earl, Mühlemann, Oliver
Subjects:	600 Technology > 630 Agriculture 500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry
ISSN:	0009-4293
Publisher:	Schweizerische Chemische Gesellschaft
Language:	English
Submitter:	Christina Schüpbach
Date Deposited:	06 Jun 2019 09:37
Last Modified:	05 Dec 2022 15:28
Publisher DOI:	10.2533/chimia.2019.374
BORIS DOI:	10.7892/boris.131147
URI:	https://boris.unibe.ch/id/eprint/131147

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The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence

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