Loiseau, Chloé; Brites, Daniela; Reinhard, Miriam; Zürcher, Kathrin; Borrell, Sonia; Ballif, Marie; Fenner, Lukas; Cox, Helen; Rutaihwa, Liliana K; Wilkinson, Robert J; Yotebieng, Marcel; Carter, E Jane; Abimiku, Alash'le; Marcy, Olivier; Gotuzzo, Eduardo; Avihingsanon, Anchalee; Zetola, Nicola; Doulla, Basra; Böttger, Erik C; Egger, Matthias; ... (2020). HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 64(10), e00782-20. American Society for Microbiology 10.1128/AAC.00782-20
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Loiseau_AntimicrobAgentsChemother_2020.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Zürcher, Kathrin, Ballif, Marie, Fenner, Lukas, Egger, Matthias |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0066-4804 |
Publisher: |
American Society for Microbiology |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Andrea Flükiger-Flückiger |
Date Deposited: |
11 Aug 2020 18:53 |
Last Modified: |
05 Dec 2022 15:39 |
Publisher DOI: |
10.1128/AAC.00782-20 |
PubMed ID: |
32718966 |
BORIS DOI: |
10.7892/boris.145586 |
URI: |
https://boris.unibe.ch/id/eprint/145586 |
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