The name tells the story: Two-pore channels.

Stoklosa, Paulina; Probst, Daniel; Reymond, Jean-Louis; Peinelt, Christine (2020). The name tells the story: Two-pore channels. Cell calcium, 89, p. 102215. Elsevier 10.1016/j.ceca.2020.102215

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TPC2-A1-N and TPC2-A1-P, two novel small molecules, differentially activate two-pore channel 2 (TPC2) and mimic the activation of TPC2 with NAADP and PIP2, resulting in distinct ion channel selectivities. These two different modes of TPC2 activity have physiological, and possibly pathophysiological, implications as they can modulate vesicle trafficking and lysosomal exocytosis.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Faculty Institutions > NCCR TransCure
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine
08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Stoklosa, Paulina Agnieszka; Probst, Daniel; Reymond, Jean-Louis and Peinelt, Christine

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
500 Science > 540 Chemistry

ISSN:

0143-4160

Publisher:

Elsevier

Language:

English

Submitter:

Barbara Järmann-Bangerter

Date Deposited:

26 Aug 2020 13:44

Last Modified:

04 Sep 2020 09:29

Publisher DOI:

10.1016/j.ceca.2020.102215

PubMed ID:

32442744

Uncontrolled Keywords:

Agonist Ion channel selectivity Lysosomal exocytosis TMAP Two-pore channel Vesicle motility

BORIS DOI:

10.7892/boris.146127

URI:

https://boris.unibe.ch/id/eprint/146127

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