Stoklosa, Paulina; Probst, Daniel; Reymond, Jean-Louis; Peinelt, Christine (2020). The name tells the story: Two-pore channels. Cell calcium, 89, p. 102215. Elsevier 10.1016/j.ceca.2020.102215
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TPC2-A1-N and TPC2-A1-P, two novel small molecules, differentially activate two-pore channel 2 (TPC2) and mimic the activation of TPC2 with NAADP and PIP2, resulting in distinct ion channel selectivities. These two different modes of TPC2 activity have physiological, and possibly pathophysiological, implications as they can modulate vesicle trafficking and lysosomal exocytosis.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Faculty Institutions > NCCR TransCure 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine 08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Stoklosa, Paulina Agnieszka, Probst, Daniel, Reymond, Jean-Louis, Peinelt, Christine |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health 500 Science > 540 Chemistry |
ISSN: |
0143-4160 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Barbara Franziska Järmann-Bangerter |
Date Deposited: |
26 Aug 2020 13:44 |
Last Modified: |
05 Dec 2022 15:40 |
Publisher DOI: |
10.1016/j.ceca.2020.102215 |
PubMed ID: |
32442744 |
Uncontrolled Keywords: |
Agonist Ion channel selectivity Lysosomal exocytosis TMAP Two-pore channel Vesicle motility |
BORIS DOI: |
10.7892/boris.146127 |
URI: |
https://boris.unibe.ch/id/eprint/146127 |
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