Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-naïve Patients.

Reichmuth, Martina L.; Hömke, Rico; Zürcher, Kathrin; Sander, Peter; Avihingsanon, Anchalee; Collantes, Jimena; Loiseau, Chloé; Borrell, Sonia; Reinhard, Miriam; Wilkinson, Robert J; Yotebieng, Marcel; Fenner, Lukas; Böttger, Erik C; Gagneux, Sebastien; Egger, Matthias; Keller, Peter Michael (2020). Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-naïve Patients. Antimicrobial agents and chemotherapy, 64(11), e00513-20. American Society for Microbiology 10.1128/AAC.00513-20

[img]
Preview
Text
Reichmuth_AntimicrobAgentsChemother_2020.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (276kB) | Preview

Mutations in the genes of the F420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, of Mycobacterium tuberculosis (Mtb) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For ten strains with mutations, we determined the minimum inhibitory concentration (MIC) of delamanid. We found one strain from a delamanid-naïve patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical MIC to delamanid.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > General Bacteriology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Mycobacteriology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Reichmuth, Martina Larissa; Zürcher, Kathrin; Fenner, Lukas; Egger, Matthias and Keller, Peter Michael

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

09 Sep 2020 21:24

Last Modified:

12 Jan 2021 08:32

Publisher DOI:

10.1128/AAC.00513-20

PubMed ID:

32868333

BORIS DOI:

10.7892/boris.146406

URI:

https://boris.unibe.ch/id/eprint/146406

Actions (login required)

Edit item Edit item
Provide Feedback