The multifaceted role of TRAIL signaling in cancer and immunity.

Cardoso Alves, Ludmila; Corazza, Nadia; Micheau, Olivier; Krebs, Philippe (2020). The multifaceted role of TRAIL signaling in cancer and immunity. (In Press). The FEBS journal FEBS Press 10.1111/febs.15637

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Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells. However, activation of TRAIL signaling may also trigger non-apoptotic pathways in cancer and in non-transformed cells, i.e. immune cells. Here, we review the current knowledge on non-canonical TRAIL signaling. The biological outcomes of TRAIL signaling in immune and malignant cells is presented and explained, with a focus on the role of TRAIL for natural killer (NK) cell function. Furthermore, we highlight the technical difficulties in dissecting the precise molecular mechanisms involved in the switch between apoptotic and non-apoptotic TRAIL signaling. Finally, we discuss the consequences thereof for a therapeutic manipulation of TRAIL in cancer and possible approaches to bypass these difficulties.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Cardoso Alves, Ludmila; Corazza, Nadia and Krebs, Philippe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1742-4658

Publisher:

FEBS Press

Language:

English

Submitter:

Philippe Krebs

Date Deposited:

24 Dec 2020 11:51

Last Modified:

24 Dec 2020 11:59

Publisher DOI:

10.1111/febs.15637

PubMed ID:

33215853

Uncontrolled Keywords:

Apoptosis Cancer Immune cell regulation NK cells Non-canonical TRAIL signaling TRAIL signaling

BORIS DOI:

10.48350/149421

URI:

https://boris.unibe.ch/id/eprint/149421

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